03-12-96. `Apotheker en AIDS, een onbekend terrein'. Tweede Nederlandse Symposium over Farmaceutische Patintenzorg. Rijksuniversiteit Groningen. Utrecht, Jaarbeurs. Abstract in Programme 08-04-97 `AIDS en apothekers, een onbekend terrein'. Wetenschapplijke Dag KNMP, Utrecht, Jaarbeurscongrescentrum. Abstract in conference papers. 23-04-98 `Pharmacotherapeutic consultations in the Netherlands'. Cont. Education course at Norske Apotekerforening, Oslo, Norway 08-05-98 `Aids en de apotheker'. Aids-symposium. Glaxo Wellcome, Zeist. 29-08-98 `Pharmacy in the Netherlands'. Eighth International Public Health Pharmacy Issues Conference, PPSI, the Hague. Abstract in abstractbook 24-11-98 `Dutch Community Pharmacy and Medication Surveillance'. Farmasidagene Norsk Farmaceutisk Selskap, Oslo. Abstract in Abstractbook. 08-05-99 `Aidsbetreuung in den Niederlanden'. Glaxo Seminar, Hamburg. Abstract in Abstractbook. 07-09-99 'Syntesis of the pharmacists interventions'. Session AIDS and Drug Addiction, FIP conference Barcelona.
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Orders within the scope of their practice and then the attending medical physician is responsible for the pneumonia inpatient stay component. The format of the pneumonia standing orders helped to remove the barrier of the ED physicians starting the pneumonia standing orders since the attending medical physician took over the inpatient pneumonia care standing orders. What also helped our antibiotic selection process was the creation of a "mini-order", a mini pneumonia pathway of the critical elements of pneumonia care, on the emergency documentation form. The form which has check-off boxes for the emergency room staff provides a concise form to document pneumonia care. This form also served as another trigger or prompt for the ED staff to complete the necessary elements for pneumonia care, for example, disopyramide norpace.
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Clinical practice, potentially increasing quit attempts in adolescents who smoke. Effectiveness of individually tailored smoking cessation advice letters as an adjunct to telephone counselling and generic self-help materials: randomized controlled trial Addiction, Volume 102, Issue 6, Page 994, June 2007 Stephen Sutton, Hazel Gilbert Abstract Objective: To evaluate the effectiveness of individually tailored smoking cessation advice letters as an adjunct to telephone counselling and generic self-help materials. Design: Randomized controlled trial. Setting: The UK Quitline. Participants: A total of 1508 current smokers and recent ex-smokers. Interventions: The control group received usual care telephone counselling and an information pack sent through the post ; . The intervention group received in addition a computer-generated individually tailored advice letter. Main outcome measures: All outcomes were assessed at 6-month follow-up. The primary outcome measure was self-reported prolonged abstinence for at least 3 months. Secondary outcomes were self-reported prolonged abstinence for at least 1 month and 7-day and 24-hour point-prevalence abstinence. Results: For the sample as a whole, quit rates did not differ significantly between the two conditions. However, among the majority n 1164 ; who were smokers at baseline, quit rates were consistently higher in the intervention group: prolonged abstinence for 3 months, 12.2% versus 9.0% [odds ratio OR ; 1.40, 95% confidence interval CI ; 0.962.04, P 0.080 prolonged abstinence for 1 month, 16.4% versus 11.3% OR 1.53, 95% CI 1.092.15, P 0.013 7-day point-prevalence abstinence, 18.9% versus 12.7% OR 1.59, 95% CI 1.152.19, P 0.004 24-hour point-prevalence abstinence, 20.9% versus 15.4% OR 1.45, 95% CI 1.071.96, P 0.015 ; . Conclusions: The results for the smokers are encouraging in showing a small but useful effect of the tailored letter on quit rate. Versions of the tailoring program could be used on the web and in general practices, pharmacies and primary care trusts, for example, atenolol.
The following are prohibited: a. Blood doping. Blood doping is the use of autologous, homologous or heterologous blood or red blood cell products of any origin, other than for legitimate medical treatment. The Use of products that enhance the uptake, transport or delivery of oxygen, e.g. erythropoietins, modified haemoglobin products including but not limited to haemoglobin-based blood substitutes, microencapsulated haemoglobin products, perfluorochemicals, and efaproxiral RSR13.
Elevated digoxin serum concentrations in patients receiving clarithromycin and digoxin concomitantly have also been reported in post-marketing surveillance. Some patients have shown clinical signs consistent with digoxin toxicity, including potentially fatal arrhythmias. Serum digoxin levels should be carefully monitored while patients are receiving digoxin and clarithromycin simultaneously. The following drug interactions, other than increased serum concentrations of carbamazepine and active acid metabolite of terfenadine, have not been reported in clinical trials with clarithromycin; however, they have been observed with erythromycin products and or with clarithromycin in post-marketing experience. Concurrent use of erythromycin or clarithromycin and ergotamine or dihydroergotamine has been associated in some patients with acute ergot toxicity characterized by severe peripheral vasospasm and dysesthesia. Erythromycin has been reported to decrease the clearance of triazolam and, thus, may increase the pharmacologic effect of triazolam. There have been post-marketing reports of drug interactions and CNS effects e.g., somnolence and confusion ; with the concomitant use of clarithromycin and triazolam. There have been reports of an interaction between erythromycin and astemizole resulting in QT prolongation and torsades de pointes. Concomitant administration of erythromycin and astemizole is contraindicated. Because clarithromycin is also metabolized by cytochrome P450, concomitant administration of clarithromycin with astemizole is not recommended. As with other macrolides, clarithromycin has been reported to increase concentrations of HMG-CoA reductase inhibitors e.g., lovastatin and simvastatin ; , through inhibition of cytochrome P450 metabolism of these drugs. Rare reports of rhabdomyolysis have been reported in patients taking these drugs concomitantly. The use of erythromycin and clarithromycin in patients concurrently taking drugs metabolized by the cytochrome P450 system may be associated with elevations in serum levels of these other drugs. There have been reports of interactions of erythromycin and or clarithromycin with carbamazepine, cyclosporine, tacrolimus, hexobarbital, phenytoin, alfentanil, disopyramide, lovastatin, bromocriptine, valproate, terfenadine, cisapride, pimozide, rifabutin, and astemizole. Serum concentrations of drugs metabolized by the cytochrome P450 system should be monitored closely in patients concurrently receiving these drugs. Carcinogenesis, Mutagenesis, Impairment of Fertility: The following in vitro mutagenicity tests have been conducted with clarithromycin: Salmonella Mammalian Microsomes Test Bacterial Induced Mutation Frequency Test In Vitro Chromosome Aberration Test Rat Hepatocyte DNA Synthesis Assay and
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Emergency contraception. Int J Clin Pract 1999 Apr-May; 53 3 ; : 199-204 Sarkar NN Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, India. Emergency contraception means preventing pregnancy after unprotected sexual intercourse. This is also called postcoital contraception PCC ; or the 'morning-after pill'. High doses of oestrogen or progestogen or a combination of both may be used as PCC up to 72 hours after unprotected intercourse. The use of mifepristone as emergency contraception has also proved promising. Some women use emergency contraception, but there are many who do not know much about it. Users, providers and other health professionals need to be educated about this method. Emergency contraception does not fall within the ambit of abortion law, yet its acceptability depends on the legal, cultural and religious consideration of most countries. This method is safe and effective and could be used occasionally to prevent unwanted pregnancy. REVIEW, TUTORIAL.
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23. Matsubara T, Clarkson C, Hondeghem L: Lidocaine blocks open and inactivated cardiac sodium channels. Naunyn Schmiedebergs Arch Pharmacol 1987; 336: 224-231 Gruber R, Carmeliet E: The activation gate of the sodium channel controls blockade and deblockade by disopyramide in rabbit Purkinje fiber. Br J Pharmacol 1989; 97: 41-50 Kodama I, Toyama J, Takanaka C, Yamada K: Block of activated and inactivated sodium channels by class-I antiarrhythmic drugs studied by using the maximum upstroke veloc and
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AN 80-year-old, previously well, longwidowed Polish woman was sent for inpatient assessment by the geriatrician attached to Domiciliary Care. One month earlier her phone, water and electricity had been disconnected and her home had been condemned. She had been moved by the council into a hostel not an aged-care residential facility ; , but a week after she moved, the aged-care assessment team was requested to intervene, as she was found to be defecating and micturating in a bucket and refusing to shower. Her only support was a son who visited only on pension day. She provided a reasonable history that demonstrated little insight into the severity of her situation. She was vague but did not demonstrate severe memory deficits. Examination revealed an MMSE of 27 30 and Frontal Assessment Battery of 12 18 moderate impairment ; . There were no specific findings on physical examination beyond malnutrition weight 39kg ; . The dementia screen was normal. Nursing staff noted she continued to refuse to shower, was hiding food in the bedside table and otherwise did little to occupy herself. Occupational therapy found that when she did shower, she required prompting and that she was poorly organised in the kitchen. Her son stated: "Mum has been like this for years". Her daughter-in-law denied any problems, saying: "This is how she has always been". Both stated she had missed a few bills but generally ate well, was able to manage her finances and washed regularly. Both wanted her discharged from hospital. The bedside interview revealed that she had a good concept of her financial assets and how she wished to dispose of them. She wanted to live with her son despite him having four dependent children. She had a reasonable concept of where she was and why she arrived in hospital. She was happy to be in hospital, as she was not paying rent! We felt she was a danger to herself because of self-neglect, and diagnosed fronto-temporal dementia of the apathetic type ; despite a lack of rapid decline and little temporal lobe dysfunction. Elder neglect, due to the family's lack of insight, was present. Diogenes' syndrome self-neglect by choice ; was considered but not felt to be important. We successfully applied to the Guardianship Board for the family to become her financial advocates and a joint state and family guardian. The state guardian was a safeguard against neglect or abuse. She was eventually placed into a Housing Trust unit, with the knowledge that the state guardian had the power to return her to hospital if there were any concerns and
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478168 Novo Nordisk to move forward on development of Dr Reddy's balaglitazone - DRF 2593. Dr Reddy's Laboratories Ltd PRESS RELEASE 2003 February 06 478217 Novo Nordisk A S NYSE: NVO ; financial statement for 2002. Novo Nordisk A S PRESS RELEASE 2003 February 06 480939 Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM PROC NATL ACAD SCI USA 2001 98 24 Amphipathic 3-phenyl-7-propylbenzisoxazoles; human PPAR , and agonists. Adams AD, Yuen W, Hu Z, Santini C, Jones AB, MacNaul KL, Berger JP, Doebber TW, Moller DE BIOORG MED CHEM LETT 2003 13 5 Annual Report 2002: Bristol-Myers Squibb. Bristol Myers Squibb Co ANNUAL REPORT 2003 March 25 514245 Merck discontinues development of MK-767 for diabetes. Merck & Co Inc PRESS RELEASE 2003 November 20 525071 Bristol-Myers Squibb: Development compounds. Bristol Myers Squibb Co COMPANY WORLD WIDE WEB SITE 2004 February 12 535305 Bristol-Myers Squibb and Merck announce global development and commercialization alliance for muraglitazar, a novel compound for diabetes. Bristol-Myers Squibb Company PRESS RELEASE 2004 April 28 535435 Merck & Co enters alliance for BMS's diabetes drug muraglitazar. Merck & Co Inc PRESS RELEASE 2004 April 28 541486 Muraglitazar, a novel non-TZD dual PPAR agonist, improves metabolic abnormalities in obese, severely diabetic db db mice. Harrity T, Chu C, Kunselman L, Ponticiello R, Cap M, Cheng P, Hariharan N DIABETES 2004 53 Abs 134-OR 541493 Glucose lowering effects of multiple dose administration of muraglitazar BMS-298585 ; , a novel PPAR dual agonist, in type 2 diabetic patients. Mosqueda-Garcia R, Frost CE, Swaminathan A, Raymond R, Nepal S, Reeves R, Gregg R DIABETES 2004 53 Abs 138-OR 542286 Muraglitazar, a novel non-TZD PPAR dual agonist, regulates genes involved in reverse cholesterol transport, stimulates cholesterol efflux, and reduces MCP1 secretion in human THP1 macrophage cells. Zhou M, Peters A, Cao G, Farrelly D, Harrity T, Cheng P, Hariharan N DIABETES 2004 53 Abs 640-P 542450 American Diabetes Association - 64th Scientific Sessions Part III ; - Overnight Report, Orlando, FL, USA. Mazucco R IDDB MEETING REPORT 2004 June 4-8 542466 Pharmacokinetics of single doses of the novel PPAR dual agonist muraglitazar BMS-298585 ; in healthy human subjects. Swaminathan A, Frost CE, Raymond R, Reeves R, Mosqueda-Garcia R DIABETES 2004 53 Abs 618-P, for instance, disopyrakide phosphate.
Targeting Biologic Markers in Asthma -- Is Exhaled Nitric Oxide the Bull's-Eye? A. Deykin Methods of Coronary Revascularization -- Things May Not Be as They Seem B. J. Gersh and R. L. Frye Statins and Cancer -- Beyond the "One Drug, One Disease" Model E. Hawk and J. L. Viner CLINICAL IMPLICATIONS OF BASIC RESEARCH Mouse Models of Gynecologic Pathology J. Boyd CORRESPONDENCE A Trial of Intrapleural Streptokinase Surgery for Asymptomatic Mitral Regurgitation Antithyroid Drugs Case 5-2005: A Man with Depression and Shortness of Breath Right Coronary Perforation Due to a Toothpick Ingested at a Barbecue and
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Kendra stared in queasy fascination at the large plant. Freehold's equivalent of a Venus flytrap and large enough to eat people. Terrific. Terrifying. She leaned a little closer as the tour of the glade continued. He listed other trees--tanglewood, forker, smoketree. A long, looping vine called hangman's noose was usually found on the gallows tree. As she stopped to rest, back against a bole and gasping for breath, he pointed out several bushes and flowers--the long, warm summers and harsh winters, both with lots of ultraviolet from Iota, created a tremendous ecological diversity. She nodded, too worn to speak, as several small animals made brief appearances and Rob told her of the larger animals out in the wilds--ninety percent of the planet--that made necessary loaded guns for travelers. "And that's something you should take care of at your earliest inconvenience, " he advised as they entered the open park center again. "A gun?" she asked, not entirely comprehending. "The city gets most of its labor in the form of petty criminals. You, as an indent, can expect to be in charge of those work details. And the perimeter park areas sometimes get wild animals, including rippers. You will need a gun." "Well, if I have to, I have to. But I don't like it, " she warned him. "You'll get used to it." "I suppose." She shrugged. The sound of a local band interfered with further conversation and she sat with him to listen for a while. The music was dissonant, loud and odd to her ears and she wondered if Earth music had any following here. The performance wound down at just about the same time Kendra decided she could take no more heat. She walked with Rob to a vendor selling beverages and selected one. "Sure that's your taste?" he asked. "I'll find out." "Okay, " he shrugged. They took their drinks and found some shade near a copse of trees on another artificial hill. Sipping, he explained more about the local lifeforms. There were two rabbit analogs. One was compact and looked a bit like an oversized kangaroo rat. It was known as a bouncer. The other, very leggy and capable of deceptive maneuvers, was called a bugs. Most of the higher animal forms were a variety of mammal analog that took evolution the next step. They had three orifices; one each for reproduction, urine and feces. Their liver functions were served by three different organs. And just about everything had enough extra bones that it slunk like a cat. The ripper was reminiscent of a leopard or a cheetah in movement, but looked more like a badger on steroids, only with long, muscular legs. It maxed out at better than 135 kph--Rob graciously translated, then gave the speed again as 365 kilometers per div. It had retractable claws and fangs and could bring down land prey the size of a rhino unassisted. Kendra agreed it might be an idea to carry a gun and hope she could think faster than an animal like that. As they stood, Kendra swayed, lights at the edge of her vision. "Woah!" she giggled. Rob helped steady her. She leaned on him and had to use him for support. "What's happening?" she asked. "Is the heat getting to me again?" "No, the Sparkle is, " he told her, taking more of her weight. "The what?" "That drink is an intoxicant and mild hallucinogen. That's why I asked if it was what.
Genomic annotation based on transient rather than permanent genetic defects. However, the application of such techniques relies heavily on understanding the interplay between genes and their expression products. Furthermore, without appropriate information management, it is difficult to assess the relevance of mouse mutagenesis studies to human health. The sequencing of the human genome and the discovery of DNA variations, including single polynucleotide polymorphisms, may facilitate discovery of biomarkers of toxicity and disease susceptibilities from genotyping and phenotyping studies with human volunteers and from genomics-based research. The significance of biotechnology, bioinformatics and human population research to the Three Rs and the development alternatives to mouse mutagenesis studies will be reviewed and
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Polimixine B ; was very difficult to be controlled and stopped because the lack of the specific antimicrobials in the stockpiles. This antibiotic is used only in pediatric practice and the dose for the adult is ten times more than for the children. How to treat simultaneously 600-700 people when the stock is for about 200 and for only 1 day? In biological crisis such situation could often occur! Speaking about the prophylaxis of the infectious diseases there many limits. They consist in efficacy of vaccination, the last of immune status, the cost of mass immunization etc. The etiologic agent used as biological weapon may differ from naturally found in the environment. Even in the absence of genetic engineering modified pathogen, the agent used as biological weapon could differ in recognizable way from the natural endemic strains in the area. In the environment natural selection and genetic drift cause continually diverge of the strains. Presence of a previous isolated or different strain could raise the suspicion of a criminal act. Approximately 70 different types of germs can be "weaponized" for use as agents of biological warfare. The term "weaponized" refers to packaging or treating an agent so that it becomes easier to distribute to a large area. For example, manufacturing anthrax spores as a fine powder increases the ability of the spores to become airborne and be inhaled. Approximately 30% of the diseases that would be caused by the known available agents can be treated However, this percentage does not take into account the potential for genetic engineering and its potential contribution to exacerbating problems caused by currently treatable organisms. In case of a natural disaster the intervention is influenced by several factors, including the disorganization of medical services. Despite that intervention is effective and safe for the emergency team. Biological attack means identification of the pathogen and until it is not characterized the external support is highly risky. Preparedness activities must be conducted from the public authorities level, including emergency network, facilities for medical assistance, communication and transportation. Reserves of medicine are crucial and involve huge funding that may be never will reimbursed. Antibiotics and vaccine are short live products that require refreshing from time to time. Community must pay for that, otherwise all effort are useless. The education of all-medical personnel and people involved in emergency situation, primary care providers and emergency personnel in dealing with bio44.
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