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The main toxicities encountered with ESHAP chemotherapy were hematologic toxicities Table 3 ; . WHO grades 3 and 4 neutropenia was observed in 65 42.2% ; and 35 22.7 % ; cycles, respectively. Grade 3 and 4 thrombocytopenia was observed in 61 39.6% ; cycles and 22 14.3% ; cycles, respectively. Neutropenic fever was noted in 20 13% ; cycles. Other side effects were nausea, vomiting, and mucositis. Alopecia was detected in all patients. Treatment-related death was observed in 2 patients, and all were non-responders to ESHAP therapy. Sepsis associated with severe neutropenia was the cause of death.
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Schizophrenia patients had prominent negative symptoms with marked alogia. Despite a comparable WAIS-R verbal score, they had lower performances in the word production tasks than the controls. In addition, the WAIS-R verbal score of the patients did not correlate with their performance, in contrast with the significant correlation observed for the controls. Thus, the lower verbal performance of the patients is likely to be an important aspect of the negative features, consistent with previous studies demonstrating a marked alteration in speech fluency in patients with such a symptom profile Allen et al. 1993; Alpert et al. 1997 ; . Because previous studies have shown that neuroleptic treatment can improve VF performance in patients Verdoux et al. 1995 ; , and here the treated and untreated patients vocalized a comparable number of words during both word production tasks, it is unlikely that the lower performance of the patients was a result of treatment. A crucial issue in functional imaging investigations using cognitive paradigms is the choice of the baseline condition. We used rest as a baseline because our main purpose was to compare schizophrenia patients with controls for regional activations and their hemispheric lateralization, rather than to isolate regions involved in a specific step of the information processing during word production. Also, our results can be compared more directly with a number of previous neuroimaging studies of schizophrenia patients during activation tasks that have used rest as a baseline condition e.g., Weinberger et al. 1986; Andreasen et al. 1992; Kawasaki et al. 1993; Steinberg et al. 1996 ; , as well as with studies investigating hemispheric dominance during word generation versus rest Parks et al. 1988; Warkentin et al. 1991; Weiler etal. 1994 ; . Choosing a verbal task on which the two groups perform at similar levels is a different research strategy. This approach looks for abnormalities attributable to diagnoses, or it may select out important aspects of the disease by focusing on unaffected neural functions. However, the lower performance of patients in VF tasks reveals a defect intrinsic to core negative symptoms such as alogia and flatness of affect Allen 1993; Alpert 1997 ; . Consequently, trying to disentangle the effect of behavioral differences associated with symptoms from "disease" effects, by experimentally matching the performances between patients and controls, has the drawback of ignoring the links between symptoms, cognitive performance, and brain function. Rather, our aim was to study the regional correlates of a cognitive defect reflecting a negative ; symptomatology. Therefore, we chose not to equalize the responses but to take into account the individual performances. This approach looks for physiological mechanisms associated with degraded performance.
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Or click the first letter of a drug name: a b c advanced search drugs & medications diseases & conditions pharmaceutical news & articles pill identifier drug interactions checker medical encyclopedia medical dictionary community forums welcome guest register or sign in my viewing history my drug list my interactions lists member offers professional information professional drug information clomipramine hydrochloride antidepressants, tricyclic systemic ; this monograph includes information on the following: 1 ; amitriptyline 2 ; amoxapine 3 ; clomipramine 4 ; desipramine 5 ; doxepin 6 ; imipramine 7 ; nortriptyline 8 ; protriptyline 9 ; trimipramine va classification amitriptyline primary: cn601 secondary: gu900; cn103; ga309; cn900 amoxapine primary: cn601 clomipramine primary: cn601 secondary: cn900; cn103 desipramine primary: cn601 secondary: cn103; cn900 doxepin primary: cn601 secondary: cn900; de890; cn103 ; ga309 imipramine primary: cn601 secondary: gu900; cn900; cn103 nortriptyline primary: cn601 secondary: cn103; cn900 protriptyline primary: cn601 secondary: cn900 trimipramine primary: cn601 secondary: ga309; cn103 commonly used brand name s ; : anafranil 3 ; apo-amitriptyline 1 ; apo-imipramine 6 ; apo-trimip 9 ; asendin 2 ; aventyl 7 ; elavil 1 ; endep 1 ; impril 6 ; levate 1 ; norfranil 6 ; norpramin 4 ; novo-doxepin 5 ; novo-tripramine 9 ; novopramine 6 ; novotriptyn 1 ; pamelor 7 ; pertofrane 4 ; rhotrimine 9 ; sinequan 5 ; surmontil 9 ; tipramine 6 ; tofranil 6 ; tofranil-pm 6 ; triadapin 5 ; triptil 8 ; vivactil 8 and
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Extrapyramidal reactions have occurred with long term use. The effectiveness of other calcium channel blockers for migraine prophylaxis is less definitive. Verapamil Isoptin ; is reported to be marginally effective in decreasing migraine frequency. Tricyclic antidepressants Amitriptyline Elavil ; is reported to be useful in migraine prophylaxis particularly for patients with coexisting depression or insomnia. The effectiveness of other tricyclic antidepressants TCAs ; has not been formally evaluated, however some experts consider nortriptyline Aventyl ; and doxepine S9nequan ; to be effective. The most common side effects associated with TCAs are anticholinergic effects, orthostatic hypotension, and drowsiness. TCAs should be avoided in patients with urinary retention, narrow angle glaucoma, or a history of seizures. Valproate Valproate, available in Canada as valproic acid Depakene ; or divalproex Epival ; , is as effective as propranolol in decreasing the frequency of migraine attacks. The effect on migraine intensity and duration is less certain as one study suggests no effect while another suggests a decrease in the and epivir.
CAPSULE ENDOSCOPY FINDINGS AND CLINICAL OUTCOMES IN PATIENTS WITH OBSCURE GASTROINTESTINAL BLEEDING Guido Costamagna, Stefano Rausei, Cristiano Spada, Piera Giuseppina Lecca, Alessandra Bizzotto, Syed Shah, Maria Riccioni Catholic University of Rome, ITALY Background: Capsule endoscopy CE ; is the preferred first line investigation in patients with obscure GI bleeding. However, the interpretation of CE findings is subject to variation resulting in differences in the reported diagnostic yield. Aim: To determine the relationship between CE findings and long-term outcome in patients with obscure GI bleeding. Methods: One hundred and thirty seven consecutive patients 77 male, 60 female; mean age 60 yrs range 8-90 ; underwent CE for obscure GI bleeding 30 ongoing overt bleeding, 60 previous overt bleeding, and 47 occult bleeding ; from January 2003 to November 2005. All patients had previous negative upper and lower GI endoscopy. The diagnostic yield, predictive value of CE findings, and clinical outcome were assessed. Results: The mean number of investigations prior to VCE was 4.3 range 1-18 ; . The small bowel was completely visualised in 103 137 75% ; patients. Capsule retention occurred in 1 patient suffering from peritoneal carcinomatosis. CE findings were positive in 56 patients 41% ; , suspicious in 52 38% ; , and negative in 29 21% ; . In order of decreasing frequency, the most common lesions seen were angiodysplasias 37.7% ; , ulcer or erosion 21.1% ; , erythematous fold 9.7% ; , blood within the small bowel lumen 9.1% ; , polyp 8.6% ; , suspected small bowel tumour 7.4% ; , and other 6.4% ; . Follow-up data was obtained in 74 patients; median follow-up 18.5 months range 0-35 ; . Of the patients with positive findings, CE diagnosis was confirmed in 27 34 79.4% ; patients 3 false positive, 2 false negative ; , 13 were treated surgically, 12 medically, 7 endoscopically, and 5 received no treatment; bleeding resolved in 65.5%. Of the patients with suspicious findings, CE diagnosis was confirmed in 15 26 57.7% ; patients 8 false positive, 3 false negative, 4 true positive ; , 3 were treated surgically, 6 medically, 2 endoscopically, and 16 received no treatment; bleeding resolved in 76.9% 70% spontaneously ; . Of the patients with negative CE, CE diagnosis was confirmed in 6 14 42.9% ; patients 3 false negative, 3 true negative 10 received no treatment, 2 were treated medically, and 2 surgically; bleeding resolved in 91% 64% spontaneously ; . Conclusions: Our findings confirm a high diagnostic yield of CE in patients with obscure GI bleeding. Positive findings are likely to reveal a treatable cause of bleeding whereas suspicious findings may be unrelated to the final diagnosis in the majority of patients, and in most of these cases bleeding resolves spontaneously.
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Pelvic inflammatory disease is the clinical syndrome resulting from the ascending spread of microorganisms from the vagina and the endocervix to the endometrium, the fallopian tubes or to contiguous structures. There are approximately 1 million cases per year. PID may include endometritis, salpingitis, tubo-ovarian abscess, and pelvic peritonitis in the US. Sexually transmitted organisms, especially Neisseria gonorrhoeae and Chlamydia trachomatis, are implicated in most cases increasingly mycoplasma genitilum is being associated; however, organisms not usually associated with sexual transmission, such as anaerobes, Gram-negative rods and streptococci may also be etiologic agents. Many women with PID have no symptoms or just mild-to-moderate lower abdominal pain and tenderness; indeed, many women with late complications of PID e.g., infertility, ectopic pregnancy ; report no history of PID. Occasionally, acute infection becomes life threatening because of extensive peritonitis, which is usually caused by a rupture of a tubo-ovarian abscess. Other complications and medical consequences include chronic pelvic pain, pelvic adhesions requiring subsequent surgery, infertility, and psychological depression. Absolute diagnostic criteria for PID remain uncertain. The "gold standard" has been laparoscopic evidence of tubal infection. Routine use of laparoscopy to diagnose PID is impractical. Therefore, less reliable clinical criteria must be used. In the past PID has been described as "mild" or "severe". These are very poor descriptors since PID reflects the site s ; of infection, not the degree of symptomatology. As stated above, women with very mild symptoms may have extensive disease and resultant infertility. A patient who meets the criteria for PID may be treated as outpatient if she appears to be reliable and does not fall into one or more of the categories listed below. A. Diagnosis The clinical diagnosis is imprecise. maintain a low threshold for PID diagnosis. Health care providers should and hydrodiuril.
Applications are invited for the Neonatal and Paediatric Pharmacists Group research award and prize, in association with Mandeville Medicines.The research award, of up to 3, 500, will enable pharmacists or technicians to undertake a project demonstrating improvements in the pharmaceutical care of neonatal or paediatric patients. The prize of 1, 500 will be awarded for the piece of published, because side affects.
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Land III, chief of the geriatric psychiatry branch of the National Institute of Mental Health, which is part of the National Institutes of Health, will have to forfeit $300, 000 in illegal proceeds and reimbursements. He will likely receive two years of supervised probation as a sentence. His ethical misdeeds came to light after a series of newspaper stories led to a congressional investigation into the federal government's premier collection of research centers based in Bethesda. NIH scientists should be paid enough so that they won't have to accept outside income. The discovery of dozens of private financial arrangements between drug companies and publicly employed scientists has embarrassed the agency in recent years. The federal prosecutors who handled the case said Dr. Sunderland "violated the fundamental rule" of being a government scientist who both oversaw a research partnership with an outside company and cut an outside deal to enrich himself on the same project. Dr. Sunderland, who was charged with conflict of interest, admitted accepting payments from Pfizer Inc. without authorization from his superiors and ethics watchdogs.According to the plea agreement, he must also complete 400 hours of community service. NIH officials have said that more than 40 scientists at the agency are thought to have engaged in outside, fee-based relationships with private companies. Almost none of them were charged with crimes. Instead, it appears that the scientists were disciplined internally or allowed to retire from the agency. It's not clear whether other scientists will be prosecuted on similar charges. Congressional leaders have said this case raises fundamental questions about the management of the National Institutes of Health, founded in 1887 and considered one of the world's foremost medical research centers.The organization currently employs more than 18, 000 people. Dr. Sunderland was required under agency rules to disclose all income earned from outside activities and travel expenses exceeding $260 that were, for instance, generic name.
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Rockingham. There may be times of extreme low instream flow e.g., drought ; when APGI will have to alter its operation of the Project in accordance with a "Low Instream Flow Protocol" in order to balance reservoir elevations and downstream flows. APGI's proposed Low Instream Flow Protocol is discussed in detail in Section B.6.6.3. APGI is proposing to operate the four Project reservoirs in accordance with a new set of operating guides as outlined in Table E.2-7 and eulexin.
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