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Million class D or class X medications were documented. Class D drugs may have benefits in pregnancy despite a risk to the fetus; class X drugs are contraindicated in women who are or may become pregnant. The most commonly prescribed teratogens were anxiolytic agents, anticonvulsants, antibiotics such as doxycycline e.g., Vibramycin, Pfizer ; , and statins. Fewer than 5% of the prescriptions were for isotretinoin. White women were prescribed potentially teratogenic drugs more often, in part because they were also more likely to be prescribed anxiolytic agents. Women with public insurance were also more likely to receive potentially teratogenic drugs than those with private insurance. Physicians who identified themselves as the patient's primary care provider were less likely to prescribe the drugs, according to their reporting. The researchers advise engaging women in shared decision-making about contraception when class D or class X drugs are involved. Although approximately 20% of the visits at which a teratogenic medication was prescribed would be expected to have included concurrent counseling about contraceptives, only 6% of visits actually did. Indeed, the researchers found no significant difference in the rates of contraceptive counseling with use of low-risk drugs and the potential teratogens. Not all teratogenic drugs are equally dangerous, they emphasize. Anticonvulsants are associated with structural deformities, and there is "growing evidence" of central ner vous system anomalies with the use of statins. Tetracyclines, which can cause tooth discoloration, and benzodiazepines, which cross the placenta but are not associated with structural deformities, are lower on the scale of risk. Source: J Med 2005; 118: 12401249.
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Study Design Administered two or more times daily Elia 199141 C 3x ; Intervention N MPH 25-90 mg day, bid ; vs. Behaviour modification + diet 9 wks ; 48 Age 6-12 Duration 9 wks Core outcomes Core: Results presented in graphs only. QoL: CGI physician C-GAS AE: Subject Treatment Emergent Symptom Scale [STESS] [physician, parents] Children's Psychiatric Rating Scale: nervous mannerisms, obsessive thinking Core: No hyp; IOWA Conners' Teacher Rating Scale: inattention overactivity QoL: Not reported AE: Not reported. Core: IOWA-C: hyperactivity parent IOWA-C: hyperactivity-inattentiveness teacher TIP: hyperactivity-impulsiveness teacher and parent ; QoL: Not reported. AE: Barkley 10-point scale: physiological, affective, overfocus, tics parents, teachers ; Core: CTRS CPRS: hyperactivity; Home Hyperactivity Scale parents ; QoL: CGI Teacher mothers psychiatrists ; AE: Not reported. Core: No hyp; IOWA Conners' Teacher Rating Scale: inattention overactivity QoL: Not reported. AE: Side effects rating from - 0 not troubling ; to 3 severe ; [counsellor, parents] Core: No hyp; IOWA Conners' Teacher Rating Scale: inattention overactivity QoL: Not reported. AE: Stimulant Drug Side Effects Rating Scale.

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A drug specified in Schedule C shall be recorded at the time of supply in a register specially maintained for the purpose in which the following particulars shall be entered: -- a ; serial number of the entry; b ; the date of supply; c ; the name and address of purchaser; d ; the name of the drug or preparation and the quantity thereof; e ; if the drug is drug specified in Schedule C, the name of the manufacturer and the batch number; f ; the signature of the person under whose supervision the sale was effected: Provided that this condition shall not apply to supply on the prescription of a registered medical practitioner or by way of wholesale dealing. 5 ; Records shall be maintained of all purchases and sales by way of wholesale dealing of durgs specified in Schedule C and such records shall include the following particulars: -- a ; the date of purchase and sale; b ; the names and addresses of the concerns from which purchased and the concerns to which sold; c ; the names of the drugs, the quantity and the batch number; d ; the name of the manufacturer. Such record shall be preserved for three years from the date of the sale of the drug. 6 ; The licence shall produce for inspection by an inspector appointed under the Act on demand all registers and records maintained under these rules, and shall supply to the Inspector such information as he may require for the purpose of ascertaining whether the provisions of the Act and rules thereunder have been observed. 7 ; Except where otherwise provided in these rules, all registers and records maintained under these rules shall be preserved for a period of not less than two years from the date of the last entry therein and oretic.

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