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Oral ziprasidone appears efficacious, and has been shown to have some limited clinical advantages over chlorpromazine and haloperidol in ameliorating negative symptoms of schizophrenia.
Coeytaux FM et al., Abortion, in: Koblinsky MA et al., eds., The Health of Women: A Global Perspective, Oxford, UK: Westview Press, 1993, for example, dementia. Risperidone Risperdal, Johnson & Johnson ; appears to be the most widely prescribed agent for the treatment of dementiarelated psychosis, probably because it is the most studied drug in the treatment of dementia-related behavioral problems. Compared with haloperidol, risperidone is more efficacious in treating dementia. The presence and severity of extrapyramidal signs for patients given risperidone were equivalent to those in patients receiving placebo and less than those noted in patients receiving haloperidol.34 The recommendation for dosing is to start with 0.25 to 0.5 mg at bedtime, with a target dose range of 0.75 to 1.25 mg at bedtime. Side effects with risperidone can be significantly reduced by using a 1-mg daily dose.3437 Risperidone has also been effective in patients with AD, vascular dementia, and mixed dementia.36 A six-week, randomized, double-blind, placebo-controlled study of 206 patients 61% women and with a mean age of 85.8 years ; showed that low-dose olanzapine 5 and 10 mg day ; was significantly superior to placebo and well tolerated in treating agitation, aggression, and psychosis in patients with AD; however, olanzapine Zyprexa, Eli Lilly ; at 15 mg day showed no significant efficacy. Somnolence was significantly more common among patients receiving olanzapine, and gait disturbance occurred in those receiving 5 or 15 mg day. The incidence of extrapyramidal signs and central anticholinergic effects at any olanzapine dose was similar in patients given placebo.38 A 10-week, randomized, double-blind, placebo-controlled study of long-term care residents with AD and psychosis compared the effects of quetiapine Seroquel, AstraZeneca ; with those of haloperidol Haldol, Ortho-McNeil ; . Results showed no improvement of psychosis with either antipsychotic agent, although both drugs relieved agitation significantly. The adverse effects of quetiapine were similar to those of placebo, and patients given quetiapine at doses up to 100 mg day experienced less somnolence compared with patients given haloperidol.39 Clozapine Clozaril, Novartis ; may be the least likely choice Table 1 Nonpharmacological Interventions in Dementia Behavioral techniques Positive reinforcement Differential reinforcement Antecedent modification Reminiscence life review Reality orientation Validation therapy Sensory interventions Touch therapy Music therapy Bright light therapy Massage therapy Exercise Environmental interventions Creating personal space Reducing stimuli such as noise Social environment modification with pet therapy, structured activities e.g., group singing, games, religious activities ; , and unstructured activities e.g., gardening ; for patients with AD, given its anticholinergic side effects and its tendency to produce agranulocytosis. Clozapine may be beneficial in treating psychosis associated with Parkinson's disease or dementia with Lewy bodies.40 The recommended initial dose is 6.25 to 12.5 mg at bedtime. Ziprasidoone Geodon, Pfizer ; is the newest atypical antipsychotic agent approved for the treatment of schizophrenia. No studies are available regarding its use in elderly patients with AD; use of the drug could be limited by a prolonged QT interval and the increased risk of ventricular arrhythmias and sudden death. Ziprasidone smpcCare department at the University of Pennsylvania's Wharton School. Danzon will answer questions involving "The International Market, " including the following: Are international price comparisons valid? What can we learn from them? How and why do prices differ between the United States and other countries? For which products are the differences greatest? Could the costs be more equitably distributed? What are the higher U.S. prices actually funding R&D versus marketing ; ? What have been the effects of GATT and NAFTA? What does the opening of China mean for pharmaceutical markets? The morning session will be followed immediately by a luncheon briefing highlighting the findings of the recently released DHHS report to the president, Prescription Drug Coverage, Spending, Utilization, and Prices. John F. Hoadley, Ph.D., director of the division of health financing policy in the office of the assistant secretary for planning and evaluation will provide an overview of the study and its findings. He will be joined by other members of the research team who will be on hand to answer questions. actual prices when studying prescription price trends. Cash Discounts--Most pharmaceutical firms offer incentives to their customers for rapid payment of invoices. The most common terms offered are a 2% discount if the full bill is paid within 10 days of receiving the invoice. Thus a wholesaler that pays the regular ex-factory price actually pays only 98% of that price if it pays within 10 days. The wholesaler that sells at cost plus 3%, then, is actually charging a markup of roughly 5%. Chargeback--This is the difference between the price a wholesaler pays a manufacturer see WAC ; and a lower contract price that has been negotiated by a hospital or managed care organization. Because of complexities of tracking products and some legal limitations, the chargeback system was developed as a means for discounted products to be sold through wholesalers. The wholesaler purchases the product at the normal list price and sells the product to hospitals or other contract customers at the discount price. The difference is then paid as a rebate to the wholesaler by the manufacturer. This rebate is called the chargeback. Class of Trade--Under federal law, all businesses that sell to the same customer type must be eligible to receive equal pricing consideration, such as discounts and special offers. To assure compliance with this law, most pharmaceutical companies have developed lists of similar customers and grouped them into different classes of trade. Pricing schedules and tactics are then developed for each class of trade. Direct Price--The price paid by retailers, before discounts, for products from those manufacturers who sell directly to nonwholesale accounts such as retailers, hospitals, private practice physicians, and public health clinics is called the direct price. Earned Margin--Earned margin is a term used by some retail pharmacists to describe the difference between the AWP and the actual product cost, as paid to the wholesaler or manufacturer. Ex-Factory Price--This is the actual selling price, before discounts, charged by the manufacturer. see WAC ; . Gross Profit Margin ; --The difference between acquisition or production cost of a product and its selling price is known as the gross profit margin. The gross profit margin does not include other costs of doing business. Loss Leader--A loss leader is a retail promotional pricing tactic in which the retailer charges a price that is below cost to entice customers into the store, hoping that the customers will make additional purchases while there. In retail pharmacy, a loss leader is not always priced below actual costs, but below AWP. It can, however, be argued and grisactin, because ziprasidone diabetes. Ziprasidone drug informationLada drkeahey at aol drkeahey at aol tue aug 15 : 53 pdt 2006 previous message: regarding mas and cnas and nurse title next message: lada messages sorted by: anne you can recommend oral medications i believe new guidelines say treat early as once dx as diabetic with consistent elevated blood sugars has truly been diabetic for 3 - 5 years and gatifloxacin. 5 September, 2006 Class 16. Printed matter, brochures, menus, business cards, table linen, napkins and mats, all made of paper and all being goods included in Class 16. Providing of food and drink; restaurant services included in Class 43, for example, neuroleptics. 53. Parkinson's Study Group. Low dose clozapine for the treatment of druginduced psychosis in Parkinson's disease. N Engl J Med. 1999; 340: 757-763. Meco G, Alessandria A, Bonifati V, et al. Risperidone for hallucinations in levodopa-treated Parkinson's disease patients. Lancet. 1994; 2: 1370-1371. Ford B, Lynch T, Greene P. Risperidone in Parkinson's disease. Lancet. 1994; 344: 681. Ellis T, Cudkowitz ME, Sexton PM, Growdon JH. Clozapine and risperidone treatment of psychosis in Parkinson's disease. J Neuropsychiatry Clin Neurosci. 2000; 12: 364-369. Goetz CG, Blasucci LM, Leurgans S, Pappert EJ. Olanzapine and clozapine. Comparative effects on motor function in hallucinating PD patients. Neurology. 2000; 55: 789-794. Connemann BJ, Schonfeldt-Lecuona C. Ziprasidonee in Parkinson's disease psychosis. Can J Psychiatry. 2004; 49: 73. Gray NS. Ziprasidone-related neuroleptic malignant syndrome in a patient with Parkinson's disease: a diagnostic challenge. Hum Psychopharmacol. 2004; 19: 205-207. Ebmeier KP, Calder SA, Crawford JR, et al. Dementia in idiopathic Parkinson's disease: prevalence and relationship with symptoms and signs of parkinsonism. Psychol Med. 1991; 21: 69-76. Mayeux R, Denaro J, Hemenegildo N, et al. A population-based investigation of Parkinson's disease with and without dementia. Relationship to age and gender. Arch Neurol. 1992; 49: 492-497. Tison F, Dartigues JF, Auriacombe S, Letanneur L, Boller F, Alperovitch A. Dementia in Parkinson's disease: a population-based study in ambulatory and institutionalized individuals. Neurology. 1995; 45: 705-708. Marder K, Tang MX, Cote L, Stern Y, Mayeux R. The frequency and associated risk factors for dementia in patients with Parkinson's disease. Arch Neurol. 1995; 52: 695-701. Aarsland D, Tandberg E, Larsen J, Cummings JL. Frequency of dementia in Parkinson disease. Arch Neurol. 1996; 53: 538-542. Hindle JV. Dementia in PD. In: Payfer JR, Hindle JV eds. Parkinson's Disease in the Older Patient. London, UK: Arnold; 2001: 3-117. 66. Green J, McDonald WM, Vitek JL, et al. Cognitive impairments in advanced PD without dementia. Neurology. 2002; 59: 1320-1324. Levy G, Schupf N, Tang MX, et al. Combined effect of age and severity on the risk of dementia in Parkinson's disease. Ann Neurol. 2002; 51: 722-729. Colosimo C, Hughes AJ, Kilford L, Lees AJ. Lewy body cortical involvement may not always predict dementia in Parkinson's disease. J Neurol Neurosurg Psychiatry. 2003; 74: 852-856. Murat E. What causes mental dysfunction in Parkinson's disease? Mov Disord. 2003; 18 suppl 6 ; : S63-S71. 70. Tiraboschi P, Hansen LA, Alford M, et al. Cholinergic dysfunction in diseases with Lewy bodies. Neurology. 2000; 54: 407-411. Monchi O, Petrides M, Doyon J, et al. Neural bases of set-shifting deficits in Parkinson's disease. J Neurosci. 2004; 24: 702-710. Thiel A, Hilker R, Kessler J, et al. Activation of basal ganglia loops in idiopathic Parkinson's disease: a PET study. J Neural Transm. 2003; 110: 1289-1301. Lewis SJ, Dove A, Robbins TW, et al. Cognitive impairments in early Parkinson's disease are accompanied by reductions in activity in frontostriatal neural circuitry. J Neurosci. 2003; 23: 6351-6356. Aarsland D, Laake K, Larsen JP, Janvin C. Donepezil for cognitive impairment in Parkinson's disease: a randomized controlled study. J Neurol Neurosurg Psychiatry. 2002; 72: 708-712. Fabbrini G, Barbanti P, Aurilia C, et al. Donepezil in the treatment of hallucinations and delusions in Parkinson's disease. Neurol Sci. 2002; 23: 41-43. Werber EA, Rabey JM. The beneficial effect of cholinesterase inhibitors on patients suffering from Parkinson's disease and dementia. J Neural Transm. 2001; 108: 1319-1325. Bullock R, Cameron A. Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson's disease: a case series. Curr Med Res Opin. 2002; 18: 258-264. Reading PJ, Luce AK, McKeith IG. Rivastigmine in the treatment of parkinsonian psychosis and cognitive impairment: preliminary findings from an open trial. Mov Disord. 2001; 16: 1171-1174. Aarsland D, Hutchinson M, Larsen JP. Cognitive, psychiatric and motor response to galantamine in Parkinson's disease with dementia. Int J Geriatr Psychiatry. 2003; 18: 937-941 and micronase.
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