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12. Cornish J, Kalivas P. Glutamate transmission in the nucleus accumbens mediates relapse in cocaine addiction. Journal of Neuroscience 2000; 20: RC89 1-5 ; . 13. Ito R, Dalley JW, Howes SR, Robbins TW, Everitt BJ. Dissociation in conditioned dopamine release in the nucleus accumbens core and shell in response to cocaine cues and during cocaine-seeking behavior in rats. Journal of Neuroscience 2000; 20: 7489-7495. Neisewander JL, O'Dell LE, Tran-Nguyen LTL, Castaneda E, Fuchs RA. Dopamine overflow in the nucleus accumbens during extinction and reinstatement of cocaine self-administration behavior. Neuropsychopharmacology 1996; 15: 506-514. Shalev U, Grimm JW, Shaham Y. Neurobiology of relapse to heroin and cocaine seeking: a review. Pharmacological Reviews 2002; 54: 1-42. Weiss F, Maldonado-Vlaar C, Parsons L, Kerr T, Smith D, Ben-Shahar O. Control of cocaineseeking behavior by drug associated stimuli in rats: effects on recovery of extinguished operantresponding and extracellular dopamine levels in the amygdala and nucleus accumbens. Proceedings of the National Academy of Sciences USA 2000; 97: 4321-4326. Kalivas PW. The development and expression of behavioral sensitization: Temporal profile of changes in gene expression. In: Moldanado R Ed. ; . Molecular biology of drug addiction. 2002. Humana Press, Totowa, NJ. 18. Nestler E. Molecular basis of long-term plasticity underlying addiction. Nature Reviews Neuroscience 2001; 2: 119-128. Swanson C, Baker D, Carson D, Worley P, Kalivas P. Repeated cocaine administration attenuates group I metabotropic glutamate receptor-mediated glutamate release and behavioral activation: A potential role for Homer 1b c. Journal of Neuroscience 2001; 21: 9043-9052 Thomas MJ, Beurrier C, Bonci A, Malenka RC. Long-term depression in the nucleus accumbens: a neural correlate of behavioral sensitization to cocaine. Nature Neuroscience 2001; 4: 1217-1223. Trantham H, Szumlinski K, McFarland K, Kalivas P, Lavin A. Repeated cocaine administration alters the electrophysiological properties of prefrontal cortical neurons. Neuroscience 2002; 113: 749.
Cerebrovascular nerve fibres and dilates pial and peripheral arteries. Neuroscience Letters 57, 91--95. He, P. & Curry, F. E. 1993 ; . Differential actions of cAMP on endothelial [Ca] and permeability in microvessels exposed to ATP. American Journal of Physiology 265, H1019--1023. Hill, S. J. 1990 ; . Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacology Reviews 42, 45--82. As for consumers, they are being targeted when they are unwell, at their most vulnerable and least able to make a decision on personal health issues. The review of DTCA in New Zealand will be interesting. PHARMAC, the Crown Entity that manages the New Zealand Pharmaceutical Schedule on behalf of the Government, actively supports a review of the legislation regulating DTCA. It is opposed to advertising of prescription medicines direct to the public and has stated it would like to see an outcome that considers the best outcome for patients and taxpayers. 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