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Dr. Gregory Curnew is assistant clinical professor, McMaster University, staff cardiologist internist and director, coronary care unit, Hamilton General Division, Hamilton Health Science Corporation, and a member of our editorial board. DERENDORF, H.: Increased erythrocyte and protein binding of codeine in patients with sickle cell disease. J. Pharm. Sci. 82: 11121117, 1993. MORGAN, D. J., GUTTMANN, A., WATSON, P. R. G., GHABRIAL, H., ELLIOTT, S. L., AND SMALLWOOD, R. A.: Effect of erythrocyte binding on elimination of harmol by the isolated perfused rat liver. J. Pharm. Sci. 85: 40 44, MORSCHES, B., BENES, P., HOLZMANN, H., AND HENRICH, B.: Zur Penetrationskinetik von Dehyroepiandrosteron durch die Erythrocytenmembran. Arch. Dermatol. Res. 270: 49 55, MOTULSKI, A. G., AND STEINMANN, L.: Arylamine acetylation in human red cells. J. Clin. Invest. 41: 1387 abstract ; , 1962. MULDER, E., LAMERS-STAHLHOFEN, G. J. M., AND VANDER MOLEN, H. J.: Isolation and characterization of 17 -hydroxy steroid dehydrogenase from human erythrocytes. Biochem. J. 127: 649 659, NERURKAR, S. G., AND GAMBHIR, K. K.: Insulin degradation by human erythrocyte lysates. Clin. Chem. 27: 607 609, NIEDERBERGER, W., LEMAIRE, M., MAURER, K., NUSSBAUMER, K., AND WAGNER, O.: Distribution and binding of cyclosporin in blood and tissues. Transplant. Proc. 15: 2419 2421, NOEL, M.: Kinetic study of normal and sustained release dosage forms of metformin in normal subjects. Res. Clin. Forum 1: 33 44, NOONAN, P. K., AND BENET, L. Z.: Formation of mono- and dinitrate metabolites of nitroglycerin following incubation with human blood. Int. J. Pharm. Amst. ; 12: 331340, 1982. NOSAL, R., ERICSSON, O., SJOQVIST, F., AND DURISOVA, M.: Distribution of chloroquine in human blood fractions. Methods Find. Exp. Clin. Pharmacol. 10: 581587, 1988. ODEH, Y. K., WANG, Z, RUO, T. I., WANG, T., FREDERIKSEN, M. C., POSPISIL, P. A., AND ATKINSON, JR., A. J.: Simulataneous analysis of inulin and 15 N2-urea kinetics in humans. Clin. Pharmacol. Ther. 53: 419 425, ORRINGER, E. P., POWELL, R. J., CROSS, R. E., ROGERS, J. F., WOJCIESZYN, O., PHILLIPS, J. C., REED, J., NG, K-T., AND BERKOWITZ, L. R.: A single-dose pharmacokinetic study of the antisickling agent cetiedil. Clin. Pharmacol. Ther. 39: 276 281, OWEN, J. A., AND NAKATSU, K.: Diacetylmorphine heroin ; hydrolases in blood. Can. J. Physiol. Pharmacol. 61: 870 875, PAGE, T., AND CONNOR, J. D.: The metabolism of ribavirin in erythrocytes and nucleated cells. Int. J. Biochem. 22: 379 383, PAPPENHEIMER, J. R., AND KINTER, W. B.: Hematocrit ratio of blood within mammalian kidney and its significance for renal hemodynamics. Am. J. Physiol. 185: 377390, 1956. ~ PAZMINO, P. A., SLADEK, S. L., AND WEINSHILBOUM, R. M.: Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors. Clin. Pharmacol. Ther. 28: 346 367, PECK, C. C., BARR, W. H., BENET, L. Z., COLLINS, J., DESJARDINS, R. E., FURST, D. E., HARTER, J. G., LEVY, G., LUDDEN, T., REDMAN, J. H., SANATHANAN, L., SCHENTAG, J. J., SHAH, V. P., SHEINER, L. B., SKELLY, J. P., STANSKI, D. R., TEMPLE, R. J., VISWANATHAN, C. T., WEISSINGER, J., AND YACOBI, A.: Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development. Clin. Pharmacol. Ther. 51: 465 473, PIAZZA, E., BROGGINI, M., TRABATTONI, A., NATALE N., LIBRETTI, A., AND DONNELLI, M. G.: Adriamycin distribution in plasma and blood cells of cancer patients with altered hematocrit. Eur. J. Cancer Clin. Oncol. 17: 1089 1096, PIRMOHAMED, M., COLEMAN, M. D., HUSSAIN, F., BRECKENRIDGE, A. M., AND PARK, B. K.: Diet and metabolism dependent toxicity of sulphasalazine and its principal metabolites toward human erythrocytes and leucocytes. Br. J. Clin. Pharmacol. 32: 303310, 1991. QUON, C. Y., AND STAMPFLI, H. F.: Biochemical properties of blood esmolol esterase. Drug Metab. Dispos. 13: 420 424, RAMBO, L., ERICSSON, O., ALVAN, G., LINDSTROEM, B., GUSTAFSSON, L. L., AND SJOQVIST, F.: Chloroquin and desethylchloroquine in plasma, serum and whole blood: problems in assay and handling of samples. Ther. Drug Monit. 7: 211215, 1985. RATGE, D., KOHSE, K. P., STEEGMUELLER, U., AND WISSER, H.: Distribution of free and conjugated catecholamines between plasma platelets and erythrocytes: different effects of intravenous and oral catecholamine administrations. J. Pharmacol. Exp. Ther. 257: 232238, 1991. REICHEL, C., VON FALKENHAUSEN, M., BROCKMEIER, D., AND DENGLER, H. J.: Characterization of cyclosponine A uptake in human erythrocytes. Eur. J. Clin. Pharmacol. 46: 417 419, REPKE, K, ., AND MARKWARDT, F.: Uber fermentative Reduktion von Oestron. Naunyn-Schmiedeberg's Arch. Exp. Pathol. Pharmakol. 223: 271279, 1954. ROLAN, P. E., PARKER, J. E., GRAY, S. J., WEATHERLEY, B. C., INGRAM, J., LEAVENS, W., WOOTTON, R., AND POSNER, J.: The pharmacokinetics, tolerability and pharmacodynamics of tucaresol 589C80; acid ; , a potential antisickling agent, following oral administration. Br. J. Clin. Pharmacol. 30: 419 425, ROOS, A., AND HINDERLING, P. H.: Protein binding and erythrocyte partitioning of the antirheumatic proquazone. J. Pharm. Sci. 70: 252257, 1981. ROSTAMI-HODJEGAN, A., LENNARD, L., AND LILLEYMAN, J. S.: The accumulation of mercaptopurine metabolites in age fractionated red blood cells. Br. J. Clin. Pharmacol. 40: 217222, 1995. RUDY, A. C., AND POYNOR W. J.: Binding of pyrimethamine to human plasma proteins and erythrocytes. Pharm. Res. 7: 10551060, 1990.
Since 1972, IDA Foundation is committed to improving access to and delivering high-quality essential medicines and medical supplies at the lowest possible price to low- and medium-income countries. IDA Foundation is an independent and self-supporting organisation: there are no shareholders and we do not receive any donations; any profit that IDA Foundation makes is channelled to the customer by lowering product prices or by investing in the quality and availability of essential medicines. IDA has acquired a strong reputation as a respected supplier to intergovernmental organisations, international and national governmental organisations, aid organisations, wholesalers serving institutional markets and other public healthcare institutions. 6. Acute Esophageal Necrosis: Report of Two Cases and Review of Literature. Lacy B, Toor A, Benson S, Rothstein R, Maheshwari Y. Gastrointestinal Endoscopy 49: 8, 527-532, Intestinal Cell Apoptosis and BCL-2 Expression. Shaposhnikov Y, Maheshwari Y, Sykes D, Weiser MM. Cell Death and Differentiation 3: 125-130, January 1996. 8. Laminin Receptor Expression in Rat Intestine and Liver During Development and Differentiation 3: 125-130, January 1996. 9. Changes in Ribosomal RNA and Ribosomal Protein Synthesis During Rat Intestinal Differentiation. Maheshwari Y, Weiser MM, Sykes D, Rao M, Tyner A. Cell Growth and Differentiation 4: 745-752, September 1993. 10. Blunt Liver Trauma at Sunnybrook Regional Trauma Unit. Hanna SS, Maheshwari Y. Canadian Journal of Surgery 28: 3, 220-223, May 1985. 11. The Effect of Portal Vein Occlusion on Liver Blood Flow in Normal and Cirrhotic Dogs. Hanna S, Maheshwari Y. Journal of Surgical Research 41: 293-300, 1986. An Analysis of Cell Cycle Characteristics and Course of Disease in ANLL. Raza A, Maheshwari Y, Brereton W, Preisler HD. American Journal of Hematology 24: 65-75, January 1987. 13. Differences in Cell Cycle Characteristics Amongst Patients with Acute Non-Lymphocytic Leukemia. Raza A, Maheshwari Y, Preisler HD. Blood 69: 6, 1647-1653, June 1987. 14. Proliferative Characteristics of Acute Non-Lymphocytic Leukemia. Raza A, Maheshwari Y, Ucar K, Myers G, Preisler HD. Acta Hematologica 77: 140-145, 1987. A New Method for Studying Cell Cycle Characteristics in ANLL Using Double Labeling with BrdU and 3HTdr. Raza A, Maheshwari Y, Yasin Z, Mandava N, Myers G. Leukemia Research 11: 12, 1079-1087, Cell Cycle and Drug Sensitivity Studies of Leukemic Cells That Appear Relevant in Determining Response to Chemotherapy in Acute Non-Lymphocytic Leukemia. Raza A, Maheshwari Y, Yasin Z, Mandava N, Myers G, et al. Seminars in Oncology 14: 2, 217-225, June 1987. ABSTRACTS: 1. Lansoprazole Associated Microscopic Colitis. Thomson, RD, Bensen SP, Toor A, Maheshwari Y. DDW, Orlando, Florida May 1999. Interim Results of the NYNEST Interferon-Ribavirin Treatment Trial in Chronic Hepatitis C Non-Responders. Krawit EL, Albertini R, Maheshwari Y, et al. AASLD, Chicago, Illinois November 1998. Even like giving them medician unless it is necessary.

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Previous studies have suggested that induction doses of pegasys, together with higher does of ribavirin, may be of value in improving outcomes in patients with heavier than average bodyweight, genotype 1 hepatitis c and a high viral load and requip.

Three hepatitis C patients have died after taking a combination of ribavirin and interferon, according to the Ministry of Health, Labor, and Welfare. The office said two of the men died of stroke and the third died of a subdural hematoma, a collection of blood inside the skull. The men had taken Schering-Plough's Rebetol ribavirin ; capsules together with Intron A interferon. Successful treatment of severe respiratory papillomatosis with intravenous cidofovir and interferon a-2b. C. Armbruster, H. Vorbach, M. Huber, C. Armbruster. #ERS Journals Ltd 2001. ABSTRACT: In contrast to uncomplicated juvenile laryngeal papillomas which may regress spontaneously, papillomatosis involving pulmonary parenchyma is associated with a poor outcome. This report represents the case of a 34 yr-old female in whom respiratory papillomatosis resulted in voice problems and recurrent pneumonias due to bronchial obstruction. A computed tomographic scan of the chest showed worsening bilateral round cavitating consolidations. Bronchoscopy revealed polypoid lesions of the right vocal cord and the midtrachea which were conrmed as squamous papillomatosis by histology. Interferon IFN ; a-2b treatment was inefcient as was cidofovir monotherapy on a maintenance basis. Six months of IFN-a-2b and cidofovir in combination led to a complete macroscopic disappearance of the laryngeal lesions and to an impressive regression of the tracheal papillomas and of the intrapulmonary consolidations. These data provide support that severe respiratory papillomatosis can be safely treated by interferon a-2b and cidofovir in combination. Probably the same mechanisms as in ribavirin plus interferon a-2b, in the treatment of patients with chronic hepatitis C, are responsible for the therapeutic success in this case. Eur Respir J 2001; 17: 830831 and ropinirole.
He praised the new nih plan and urged congress to fund critical global and domestic priorities in fiscal 2001, such as $116 million for international aids programs in the department of health and human services, a $1 billion vaccine tax credit, more than $ 1 billion in aids-related research at nih, a $105 million increase for domestic hiv prevention activities at the centers for disease control and prevention and a $228 million increase for the ryan white program. Ribavirin, interferon alpha and other lotrisone immunomodulatory drugs have all been used, but without convincing results and tretinoin.

Feed source: ezinearticles traveler beware - use this handy motion sickness medication guide - it is important to be able to enjoy your holiday, but you should not take medications that could be dangerous to you. Section 17.5 of the Environmental Protection Act [415 ILCS 5 17.5] provides that Title VII of the Act and Section 5 of the Administrative Procedure Act APA ; shall not apply. Because this rulemaking is not subject to Section 5 of the APA, it is not subject to First Notice or to Second Notice review by the Joint Committee on Administrative Rules. Rather, the Board will cause a Notice of Proposed Amendments to appear in the Illinois Register, and it will accept public comments on the proposal for 45 days after the date of publication. q ; Parts Headings and Code Citations ; : LABORATORY ACCREDITATION RULES 35 Ill. Adm. Code 611 ; 1 ; Rulemaking: No docket presently reserved. A ; Description: THE IEPA PROPOSAL WILL SEEK TO AMEND THE PUBLIC WATER SUPPLIES RULES FOUND IN 35 ILL. ADM. CODE 611 TO CROSS REFERENCE THE IEPA'S OWN LABORATORY ACCREDITATION RULES FOUND AT 35 ILL. ADM. CODE 186. THESE PROSPECTIVE AMENDMENTS TO SECTIONS 611.359, 611.611, 611.646, AND 611.648 WOULD CROSS-REFERENCE THE ILLINOIS ENVIRONMENTAL PROTECTION AGENCY'S IEPA'S ; LABORATORY ACCREDITATION RULES AT 35 ILL. ADM. CODE 186. CURRENTLY, THE EXISTING TEXT OF PART 611 REFERENCES 35 ILL. ADM. CODE 183, WHICH ARE JOINT RULES OF THE IEPA, THE ILLINOIS DEPARTMENT OF PUBLIC HEALTH, AND THE ILLINOIS DEPARTMENT OF NUCLEAR SAFETY. A REPEAL OF PART 183 HAS BEEN COMPLETED. B ; Statutory Authority: Sections 27 and 28 of the Illinois Environmental Protection Act [415 ILCS 5 27 & 28] and retrovir.
In the last 15 years, a variety of strategies aimed at improving treatment outcome have been tested around the world, including patients' incentives, tracing default patients, taking legal sanctions, and improving staff motivation or treatment supervision.14, 15 These interventions were generally targeted at a single element of control eg, treatment delivery ; and showed variable success. Of 3 RCTs conducted to compare selfadministered with directly-observed therapy, 16-18 2 trials showed that there was little to be gained by DOT only, 16, 18 because approximately 30% of patients in these populations interrupted treatment before completion whatever the methods of treatment supervision. This opened the way to multitargeted approaches, a concept we used in this study, targeting together health staff, patients, and communities.8, 15 Defaulting from treatment is one of the most important problems in TB control.3, 4 Studies performed in Madagascar19 and in India20 showed that the lack of information, poor communication with health staff, and lack of attention and support at the clinic were some of the many factors affecting patients' adherence to treatment. In our qualitative study, we found that the health staff can play a key role in achieving adherence to treatment, justifying the training component of the tested strategy and the need for improved counseling.9 Access to health care is the cornerstone of TB control programs that must ensure that patients receive a full course of treatment. In areas in which patients live far from health centers, the positive effect of free treatment is often offset by indirect transportation costs, and patients might prefer to give up treatment due to these costs.5 The qualitative study suggested that access to drugs would be improved through decentralization of treatment.9 Our findings are consistent with those reported from several countries in Africa, 21-23 in which decentralization was shown to be effective overall, although the magnitude of the effect on treatment outcome varied according to the country, the type of treatment, and the site identified for treatment delivery. Aarp poll shows most support legalizing medicinal marijuana and rifater. Dear Pharmacy Provider, ProDUR HIGH DOSE ALERT Beginning August 8, 2005, Oklahoma Medicaid will begin to deny claims submitted with doses greater than two times the FDA recommended maximum dose. Please submit the correct day supply, so that, the submitted claim does not deny due to error. If a ProDUR High Dose Alert is received, a prior authorization may be requested by submitting a Statement of Medical Necessity for Quantity Limit Override form. All pharmacy forms can be accessed at the following link: : ohca ate.ok provider pharmacy billing forms, because ribavifin capsule. Ribavirin in generally thought talwin this promising librax the degree authority and rifampin.
Ribavirin, 1--D-ribofuranosyl-1, 2, 4-triazolo-3-carboxamide, is a broad spectrum antiviral agent1 which also displays antitumor activity in mice.2 It is a FDA approved anti-HIV drug with the trade name Virazole and has attracted considerable attention because of a peculiar mechanism of action related to IMPDH inhibition via its anabolite 5-monophosphate.3 Ribavifin is also endowed with the capability of potentiating in vitro anti-HIV-1 activity of purine dideoxynucleosides. It is currently under clinical studies in combination with -interferon for the treatment of patients with chronic hepatitis C.4 Recently, pyrazole nucleosides have been synthesized as carbon bioisosteres of ribavirin, and some of them, 4-substituted 3-carboxamido derivatives of type 1 R NH2, R' NO2, Hal ; , emerged as selective in vitro inhibitors of human T and B leukemias and lymphomas and coxsackie B1 virus.5 It is well known that the activity of rubavirin is related to steric and hydrogen-bonding requirements at the primary amide at C-3 position. However in the second generation of the glycosidopyrazoles of type 1, it has been reported that the presence of the carboxamido function is not necessary for the appearance of the activity, since also 4-halo-3-methoxyesters showed activity against a panel of tumor cell lines, and in particular, 1--D-ribofuranosyl-4-iodo-3. Side Effects Abdominal Distress Anxiety and Depression Management Strategy Lactose-free diet with cooked vegetables Antidiarrheals Exercise Avoid stimulates like caffeine Make sure you tell your nurse practitioner May need medications while on treatment Can change dose of interferon if too bad Don't be afraid to share this information early in therapy, it can catch up with you fast Start SSRIs 2-6 weeks prior Other anti-anxiety meds See psychiatrist if severe Lemon drops Dark chocolate If you get mouth sores please tell your nurse practitioner so we can prescribe some medicine for you Use saline drops or natural tears See ophthalmologist if poor vision Cut nails short Use biotin, zinc, or glucosamine chondroitin Use petroleum jelly or olive oil Avoid nail salons, polish and biting Increase fluids Chew sugarless gum or sour balls Drink at least 1 gallon of water a day Avoid caffeine Water down juices, Gatorade, Crystal Light Lemon in water Antidiarrheals Imodium Fiber cereal, toast Avoid juices BRAT diet bananas, rice, apple sauce and toast Eat foods that are not spicy Side Effects Dry Skin Management Strategy Drink 1 gallon water per day Use lotions like Lachydrin or Aquaphor Decrease baths and showers Avoid hot water Evening administration of interferon Low impact exercise "Cat nap" after work Eat a healthy low-fat, high complex carb diet. Multiple small meals, 1 gal water day, exercise Avoid cannabis, alcohol, OTC quick energy products, vitamin supplements, excess caffeine Wide tooth comb Satin pillow case Use biotin or hair growth shampoos Cut hair short Avoid dying, bleaching, perming, straightening, tight braids and daily shampoo Increase your fluid intake NSAIDS or Tylenol if it is okay with your nurse practitioner Relaxation Reduce stress Rest, exercise and healthy diet Acupuncture Make sure develop a sleep pattern same time to bed each night ; Stay in bed if you can't sleep Limit afternoon naps in length of time Try to limit fluid intake to earlier in the days so not up to bathroom all night If you sweat at night, bring towel to bed, so that you can put that under you after you are sweating, so that your bed stays dry If Rjbavirin makes you jittery, take at 4-5 instead of before bedtime Try warm bath, warm milk, soft music, Melatonin, SSRIs continued and risperidone. The differences in SVR rates between flat-dose and weight-based 5ibavirin were greater among patients in the subanalysis than among patients in the WIN-R study population as a whole, he said. In the subanalysis, 6% of patients had hemoglobin levels below 10 g dL, and 6% had absolute neutrophil cell counts lower than 750 mm3. In the larger study, the respective rates for these adverse events were 16% and 19%, Dr. Jacobson said. Dose reductions of peginterferon required by study protocol for hemoglobin levels lower than 10 g dL ; occurred in 18% of the patients in the subanalysis, and dose reductions of ribavirin required for hemoglobin levels lower than 8.5 g dL ; occurred in 20%, he said. The lower rates of anemia and neutropenia and the low dose-reduction rates among patients in the subanalysis "probably reflect lower levels of ribavirin exposure, " Dr. Jacobson said. The findings of this study suggest "that severe obesity should not preclude consideration of antiviral therapy for patients with chronic HCV, " he said. Dr. Jacobson reported receiving research support for this study from Schering-Plough, manufacturer of PEG-Intron. The mdr1-type or drug-transporting P-glycoproteins P-gps ; 1 were discovered by their ability to confer multidrug resistance MDR ; to mammalian tumor cells. These large plasma membrane proteins can actively transport a wide range of structurally diverse cytotoxic drugs out of the cell, rendering it resis and roxithromycin. 7: 00 shower, 7: 30 breakfast, 8: 00 take bus to work, 8: 30 check mail, 9: 30 dictate letters, 10: 00 coffee, 10: 30 staff meeting, 12: 00 lunch, 1: 00 return phone calls, 2: 30 review accounting, 4: 00 open meeting to schedule with customers, 5: 00 take bus home, 6: 00 dinner, 7: 00 family time with kids, 8: 30 time with spouse, 9: 30 read, 10: 00 lights out. A central location could be established for posting a daily schedule. Persons who never before used daily planners or computer calendars may need to start. A centralized message center can be used to make lists and organize tasks to be accomplished each day. Additional strategies for dealing with poor organization are offered in Table 6.
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How did switching from twice daily to once daily medicines make things for you? A lot easier A little more difficult Please give reasons: A little easier A lot more difficult No difference and reboxetine and ribavirin, for example, ribavirin cost. 1. 2. 3. Tseng A. tthhivclinic , General Hospital, Toronto, 2004. Clinical Pharmacology, Gold Standard Multimedia, 2004. : gsm Foisy MM, Slayter KL, Hewitt RG, et al. Pancreatitis during intravenous pentamidine therapy in an AIDS patient with prior exposure to didanosine. Ann Pharmacother 1994; 28: 1025-8. : amedeo lit ?id 7803875 Landau A, Batisse D, Piketty C, et al. Lack of interference between ribavirin and nucleoside analogues in HIV HCV co-infected individuals undergoing concomitant antiretroviral and anti-HCV combination therapy. AIDS 2000; 14: 1857-8. : amedeo lit ?id 10985327 Hittinger G. Mitochondrial toxicity in HIV HCV co-infected patients treated with ribavirin, interferon alpha and antiretroviral therapy. Abstract TuPeB4516, XIV Int AIDS Conference 2002, Barcelona. Smith DM, Puoti M, Sulkowski, et al. Symptomatic hyperlactatemia during a large hepatitis C treatment trial in HIV HCV co-infected participants on stable antiretroviral therapy. Abstract MoOrB1059, XIV Int AIDS Conference 2002, Barcelona. Medical cannabis users is subject to the same negative implications of law enforcement and penalization. References: Grotenhermen F. Review of unwanted actions of Cannabis and THC. In: Grotenhermen F, Russo E, editors. Cannabis and cannabinoids. Pharmacology, toxicology, and therapeutic potential. Binghamton NY: Haworth Press, 2002: 233-48 and sodium.

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Countries Botswana, Eritrea, Gambia, Ghana, Kenya, Lesotho, Liberia, Malawi, Mozambique, Namibia, Nigeria, South Africa, Swaziland, Tanzania, Uganda, Zambia, Zimbabwe; Ethiopia, Mauritius, Seychelles and Sierra Leone were invited but did not attend ; . The purpose was to chart progress in implementation of micronutrient deficiency control programs, to examine national monitoring systems for salt iodization, and to review strategies for the control of vitamin A deficiency. The participating countries have made tremendous progress in implementing USI. Only four Botswana, Gambia, Lesotho, Liberia ; do not have legislation in place. Monitoring systems, however, remain weak, especially for biological indicators. Only Zimbabwe has reported iodine-induced hyperthyroidism. Progress in control of vitamin A and iron deficiencies has been much slower. Some countries have started vitamin A capsule distribution linked to national immunization days. Dr. John Clements fro m the EPI program at WHO Geneva argued in favor of this approach. Trials of triple fortification of salt are ongoing in Ghana. The workshop recommended that countries adapt and harmonize legislation on human and animal salt iodization at the regional level, especially with regard to iodine concentration and salt at production site, on the basis of the 1996 ICCIDD WHO UNICEF recommendations, with regional bodies playing a more active role in the process. The participants supported sentinel sites as the most appropriate way for monitoring programs for micronutrient deficiency control, and recommended that the Task Force for Control of Micronutrient Deficiencies in Africa develop guidelines on criteria for selecting sentinel sites. The Task Force should also establish criteria for selection of regional reference labs to ensure validity and reliability of assay results, and should set up and maintain a list of laboratory facilities in the region. All countries should have independent officially designated control laboratories for measurement of iodine in salt by titration. In countries where facilities for measurements of iodine status urinary iodine, thyroid hormones ; , vitamin A status retinol ; , iron status serum ferritin ; are not available, intercountry cooperation should be encouraged and strengthened. The workshop recommended that strategy for vitamin A deficiency control should include a combination of supplementation, food diversification, fortification and public health measures, with more emphasis to a foodbased approach. Surveys of anemia should investigate the relative importance of iron.

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