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Before and during pregnancy. Nelson and Ellenberg suggested that these cerebral palsy-related prebirth factors may increase fetal vulnerability to LDCs, in which case the LDCs would still have etiological relevance. In contrast, most of the schizophrenia researchers cited above describe the Nelson and Ellenberg study as demonstrating that LDCs are etiologically meaningless consequences of previous events and conditions. LDCs have been a common feature of previous findings of early trauma among preschizophrenia persons McNeil 1988a, 1995 ; , so an understanding of their etiological significance would further our conceptualization of schizophrenia's cause. Previous empirical studies of early trauma among patients with schizophrenia do not provide a direct basis for determining whether prenatal abnormality is in fact related to subsequent LDCs McNeil 1995 ; , so a number of different relationships could potentially exist between prenatal and labor-delivery events. If prenatal abnormality caused labor-delivery complications, then a significant positive correlation would be found between pregnancy complications and LDCs; preschizophrenia individuals with signs of abnormal prenatal development e.g., reduced head circumference at birth, high rates of MPAs, large within-twin-pair differences on birthweight per Lewis et al. 1987 ; would have increased rates of LDCs, as compared with other preschizophrenia individuals; and preschizophrenia individuals with a history of prolonged, or possibly also precipitous, labor which have been discriminating characteristics of their OCs; McNeil et al. 1994& ; would have more signs of abnormal prenatal development than other preschizophrenia individuals. Furthermore, if genetic factors in schizophrenia are implicated in abnormal prenatal development, then a relationship should be found between congenital malformations and LDCs among individuals at inferred genetic risk offspring of mothers with schizophrenia ; . In contrast, if prenatal trauma maldevelopment and LDCs represented independent or different sources of influence related to schizophrenia as suggested by McNeil et al. 1996 ; , then prenatal influences and LDCs would be unrelated or negatively related to one another among preschizophrenia individuals or individuals at genetic risk. These predictions were tested in the current study using data from singleton and twin schizophrenia samples, as well as high-risk cases, for example, retin a body.
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