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RUTH ORATZ, MD, FACP: That's a very important issue, the interaction of all of the different medicines, one with the other, and then particularly the interaction of the SSRI drugs with tamoxifen. Ironically, one of the treatments that we sometimes recommend for hot flashes is SSRIs. We don't know the mechanism of how that works, and maybe one of the ways it's working is that it's lowering the activity of the tamoxifen somehow. The issue is that these drugs are metabolized by different pathways in the liver, and different medicines can interfere with the metabolism of drugs. In some patients it was shown that if they took the SSRI antidepressant, they may not be getting as much of a benefit from tamoxifen [as] women who were not taking those antidepressants. That's a fine balance, because if you need to be treated with an antidepressant, then one of the considerations might be to try a different class of drugs, a nonSSRI drug. There are a couple of those out there on the market. You'd have to speak with your psychiatrist or psychopharmacologist as well as your medical oncologist if that's a concern. That concern has not been raised with the aromatase inhibitors. But you're right. There was a study that showed that, so that's something we should think about. CALLER: Thank you. ELYSE S. CAPLAN, MA: Ruth, before we move on to the next question could you identify the names of the medicines that fall into the SSRI category, as some women are unfamiliar with those medicines? RUTH ORATZ, MD, FACP: That's a good point, Elyse. The most common and the oldest SSRI that's been on the market is Prozac. Zoloft and Paxik would be the other most common ones. There may be a few others. I think maybe Celexa also. ELYSE S. CAPLAN, MA: I think Effexor also. RUTH ORATZ, MD, FACP: I'm not sure if Effexor is an SSRI. I would have to look that up. [Note: Effexor is an SNRI: serotonin-norepinephrine reuptake inhibitor. SNRIs and SSRIs both act on the neurotransmitter in the brain called serotonin; SNRIs also act on the neurotransmitter norepinephrine.].
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Zhongguo Zhong Yao Za Zhi. 2006 Jan; 31 2 ; : 145-8. [Effects of traditional tibetan medicine, Fructus Lonicerae microphyllae on phagecytosis and cytokines production of murine macrophages] Article in Chinese Wang JL, Sun Y, Zhou HY, Xu Q, Dun Z. Department of Pharmacology, School of Medicine, Tibet University, Lasa 850000, China. jule-wang 163 OBJECTIVE: To explore the effects of traditional Tibetan medicine, Fructus Lonicerae microphyllae FLM ; on phagecytosis and cytokines production of murine macrophages. METHOD: The phagecytosis of murine macrophages was analyzed by neutral red phagecytosis assay. The activities of IL-1 and TNF-alpha were measured by biological methods. The mRNA of TNF-alpha and INF-gamma expressed by macrophages was detected by RT-PCR. RESULT: The phagecytosis of murine macrophages was significantly enhanced by FLM at a concentration from 1 microg x mL -1 ; to 100 microg x mL -1 ; and the secretions of IL-1, and TNF-alpha from macrophages were markedly induced by FLM. Meanwhile, FLM also increased the expression of TNFalpha mRNA and INF-gamma mRHA from macrophages in vitro. CONCLUSION: FLM could promote phagecytosis and cytokines production of murine macrophages. Regardless of the transition plan chosen, a national "spectrum registry", comparable to local land registries, should be established and maintained. In principle, one or more private entities could maintain the registry; or, following the practice in real estate, a government entity could maintain the registry. In the latter case, either the FCC or the NTIA would be logical organizations in which this function should be housed. The purpose of the registry would be to facilitate spectrum transactions and to assist in the enforcement of property rights. 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Hydrocodone and paxil drug interactionReceived July 13, 1992. Address all correspondence and requests for reprints to: Dr. R. V. Jackson, Neuroendocrine Research Unit, University Department of Medicine, Greenslopes Hospital, Newdegate Street, Greenslopes, Brisbane, Queensland 4120, Australia. * Presented in part at the 34th Annual Scientific Meeting of the Endocrine Society of Australia, Sydney, Australia, September 199 1. This work was supported by grants from the Department of Veterans Affairs, the Commonwealth of Australia, and the Mayne Bequest Fund of the University of Queensland. t Supported by the E. S. Tooth Research Scholarship of the University of Queensland. Filed U S 5 before The Patents Amendment ; Ordinance, 2004: NO 57 ; Abstract: A antimicrobial wipe suitable for the hygienic cleaning of surfaces, which comprises a substrate incorporating an aqueous composition comprising: i ; at least one surfactant ii ; at lest one acid, and iii ; a solvent which is an N-alkylpyrrolidone derivative Figure Sheets.NIL Total Pages: 21 FIG.NIL and premarin and paxil, for instance, generalized social anxiety disorder. Being supplied the programming, human contact and psychiatric support that seriously mentally ill inmates need to prevent their illnesses from escalating, inmates at Supeimax are kept isolated from all other humans, whether guards, other inmates or family members. They are given no programming unless they progress out of the lower levels of the incentive program and they receive limited psychiatric support. Many of the severe conditions serve no legitimate penological interest; they can onlybe considered punishment for punishment's sake . Not surprisingly, the mentally ill inmates identified by plaintiffs rarely progress out of Level One of the incentive program or, if they do, their upward movement is only temporary. An exception is Prisoner 2, who bounces between Levels One and Two and has had a short stay on Level Three. These inmates are stuck in the lowest levels, a circumstance that by itself suggests the inappropriateness of subjecting such persons to an incentive program that is so all encompassing and harsh. As former Secretary Sullivan testified, the Wisconsin Resource Center was developed for the very purpose of helping inmates who got "stuck" in segregation . Because I find that the conditions about which plaintiffs complain are particularly harsh with respect to seriously mentally ill inmates, I do not need to reach the question whether defendants failed to provide them adequate medical treatment. 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