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If there is an adverse outcome in our pending litigation, such as the securities class action litigation that has been filed against us, our business may be harmed. We and certain of our officers and directors are named as defendants in a purported securities class action lawsuit filed in August 2003 in the U.S. District Court for the Northern District of California captioned Crossen v. CV Therapeutics, Inc., et al. The lawsuit is brought on behalf of a purported class of purchasers of our securities, and seeks unspecified damages. As is typical in this type of litigation, several other purported securities class action lawsuits containing substantially similar allegations were filed against the defendants. In November 2003, the court appointed a lead plaintiff, and in December 2003, the court consolidated all of the securities class actions filed to date into a single action captioned In re CV Therapeutics, Inc. Securities Litigation. In January 2004, the lead plaintiff filed a consolidated complaint. We and the other named defendants filed motions to dismiss the consolidated complaint in March 2004. In August 2004, these motions were granted in part and denied in part. The court granted the motions to dismiss by two individual defendants, dismissing both individuals from the action with prejudice, but denied the motions to dismiss by us and the two other individual defendants. After the motion to dismiss was decided, this action entered the discovery phase, and discovery in the action is ongoing. In addition, certain of our officers and directors have been named as defendants in a derivative lawsuit filed in August 2003 in California Superior Court, Santa Clara County, captioned Kangos v. Lange, et al., which names CV Therapeutics as a nominal defendant. The plaintiff in this action is one of our stockholders who seeks to bring derivative claims on behalf of CV Therapeutics against the defendants. The lawsuit alleges breaches of fiduciary duty and related claims based on purportedly misleading statements concerning our new drug application for Ranexa. At the appropriate time, we expect to file a motion to dismiss this lawsuit due to the plaintiff's unexcused failure to make a demand on us before filing the action. As with any litigation proceeding, we cannot predict with certainty the eventual outcome of pending litigation, and defending these lawsuits is likely to be costly, time-consuming and uncertain. Accordingly, no accrual has been established for these lawsuits. In the event of an adverse outcome, our business could be harmed. Our operations involve hazardous materials, which could subject us to significant liability. Our research and development and manufacturing activities involve the controlled use of hazardous materials, including hazardous chemicals, radioactive materials and pathogens, and the generation of waste products. Accordingly, we are subject to federal, state and local laws governing the use, handling and disposal of these materials. We may have to incur significant costs to comply with additional environmental and health and safety regulations in the future. We currently do not carry insurance for hazardous materials claims. We do not know if we will be able to obtain insurance that covers hazardous materials claims on acceptable terms with adequate coverage against potential liabilities, if at all. Although we believe that our safety procedures for handling and disposing of hazardous materials comply in all material respects with regulatory requirements, we cannot eliminate the risk of accidental contamination or injury from these materials. In the event of an accident or environmental discharge, we may be held liable for any resulting damages, which may exceed our financial resources and may materially adversely affect our business, financial condition and results of operations. Although we believe that we are in compliance in all material respects with applicable environmental laws and regulations, there can be no assurance that we will not be required to incur significant costs to comply with environmental laws and regulations in the future. There can also be no assurance that our operations, business or assets will not be materially adversely affected by current or future environmental laws or regulations. Changes in accounting rules for stock-based compensation will adversely affect our operating results, and may adversely affect our stock price and our competitiveness in the employee marketplace. We are required to adopt SFAS No. 123 revised 2004 ; , Share-Based Payment, or SFAS 123R, on January 1, 2006. SFAS 123R requires all share-based payments to employees and directors, including grants of 40.

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8: 10 Variability Of Prostate Brachytherapy Preimplant Dosimetry: A Multi-Institutional Analysis Gregory S. Merrick, M.D., 1 Wayne M. Butler, PH.D., 1 Kent E. Wallner, M.D., 1 John C. Blasko, M.D., 1 Jeff Michalski, M.D., 1 Jesse Aronowitz, M.D., 1 Peter Grimm, D.O., 1 Brian J. Moran, M.D., 1 Patrick McLaughlin, M.D., 1 Jacqueline Usher, B.S., 1 Jonathan Lief, PH.D., 1 Zachariah Allen, M.S.1 Intraoperative Fluoroscopic-Based Dosimetry In Prostate Brachytherapy Patients Daniel R Reed, DO, 1, 2 Kent E. Wallner, MD, 1, 2 Sreeram Narayanan, PhD, 1, 2 Gregory Merrick, MD, 3 Wayne Butler, PhD, 3 Steve Sutlief, PhD, 2 Paul Cho, PhD.1, 2 Dosimetric Comparison Of Three Intra-Operative Computer Planning Options For Permanant Seed Implantation Of The Prostate Adam Raben, MD, 1 Sarah Sammons, BA, 1 Sang Sim, MD, 2 Hansen Chen, MS, 2 Alex Hanlon, PhD, 1 Abhirup Sarkar, MS, 1 Arnold Grebler, MD, 2 Jules Geltzeiler, MD, 2 Bruce Benge, MD, 1 Andrew Glick, MD, 1 Alex Hanlon, PhD, 1 Paul Koprowski, BA, 1 Viroon Donavanik, MD.1 Prostate Brachytherapy-Induced Urethral Strictures Gregory S. Merrick, MD, 1, 2 Wayne M Butler, PHD, 1, 2 Kent E. Wallner, MD, 3 Robert W. Galbreath, PHD, 1, 2 Richard L. Anderson, RTT, CMD, 1 Zachariah A. Allen, MS.1, 2 I-125 Versus Pd-103 For Low Risk Prostate Cancer: Morbidity Outcomes From A Prospective Randomized Multi-Center Controlled Trial Andrew Herstein, 1 Kent Wallner, M.D., 1, 2 Gregory Merrick, M.D., 3 Paul Mitsuyama, M.D., 1, 2 Julius Armstrong, RTT, 2 Lawrence True, M.D., 4 William Cavanagh, B.A., 2 Wayne Butler, PH.D.3 Risk Factors Associated With Urinary Retention Following Permanent 125i Prostate Brachytherapy: A Retrospective Multivariate Analysis Of 1, 286 Monotherapy Patients David Linstadt, MD, 1 Mark Logsdon, MD, 1 Steve Workman, MD, 2 Larry Goldman, MD, 2 Michael Russo, MD, 2 Deepak Chabra, MD, 2 Dwight Stickney, MD.1 Predictive Factors For Erectile Dysfunction In Men With Prostate Cancer Following Prostate Brachytherapy: Is Dose To The Penile Bulb Important? Graham Macdonald, MD, 1 Mira Keyes, MD, 1 Alexandra Kruk, RTT, 2 Graeme Duncan, MD, 1 Veronika Moravan, Msc, 3 James Morris, MD.1 Refreshment Break Proffered Papers - Physics Ali S. Meigooni, Ph.D. University of Kentucky Medical Center Lexington, KY Phillip Devlin, MD Harvard Medical School Boston, MA 9: 40 On The Inadvertent Under-Dosing Of A Complex Spheriod Instilled With P-32 Chromic Phosphorous Colloid Charles D. Hechtman, Z Li, Perry Grigsby and Mark Dicocco, Washington University, St. Louis, MO 8: 20 8 and fludrocortisone.
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