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Anandamide uptake with negligible capsaicin-like activity. FEBS Lett 483: 5256, 2000. DESARNAUD F, CADAS H, AND PIOMELLI D. Anandamide amidohydrolase activity in rat brain microsomes. Identification and partial characterization. J Biol Chem 270: 6030 6035, DEUTSCH DG AND CHIN SA. Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist. Biochem Pharmacol 46: 791796, 1993. DEUTSCH DG, LIN S, HILL WA, MORSE KL, SALEHANI D, ARREAZA G, OMEIR RL, AND MAKRIYANNIS A. Fatty acid sulfonyl fluorides inhibit anandamide metabolism and bind to the cannabinoid receptor. Biochem Biophys Res Commun 231: 217221, 1997. DEVANE WA AND AXELROD J. Enzymatic synthesis of anandamide, an endogenous ligand for the cannabinoid receptor, by brain membranes. Proc Natl Acad Sci USA 91: 6698 6701, DEVANE WA, DYSARZ FA, JOHNSON MR III, MELVIN LS, AND HOWLETT AC. Determination and characterization of a cannabinoid receptor in rat brain. Mol Pharmacol 34: 605 613, DEVANE WA, HANUS L, BREUER A, PERTWEE RG, STEVENSON LA, GRIFFIN G, GIBSON D, MANDELBAUM A, ETINGER A, AND MECHOULAM R. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258: 1946 1949, DIAMOND JS. Neuronal glutamate transporters limit activation of NMDA receptors by neurotransmitter spillover on CA1 pyramidal cells. J Neurosci 21: 8328 8338, DIANA MA, LEVENES C, MACKIE K, AND MARTY A. Short-term retrograde inhibition of GABAergic synaptic currents in rat Purkinje cells is mediated by endogenous cannabinoids. J Neurosci 22: 200 208, DI MARZO V, BREIVOGEL CS, TAO Q, BRIDGEN DT, RAZDAN RK, ZIMMER AM, ZIMMER A, AND MARTIN BR. Levels, metabolism, and pharmacological activity of anandamide in CB 1 ; cannabinoid receptor knockout mice: evidence for non-CB 1 ; , non-CB 2 ; receptor-mediated actions of anandamide in mouse brain. J Neurochem 75: 2434 2444, DI MARZO V, FONTANA A, CADAS H, SCHINELLI S, CIMINO G, SCHWARTZ JC, AND PIOMELLI D. Formation and inactivation of endogenous cannabinoid anandamide in central neurons. Nature 372: 686 691, DI MARZO V, GOPARAJU SK, WANG L, LIU J, BATKAI S, JARAI Z, FEZZA F, MIURA GI, PALMITER RD, SUGIURA T, AND KUNOS G. Leptin-regulated endocannabinoids are involved in maintaining food intake. Nature 410: 822 825, DI MARZO V, LASTRES-BECKER I, BISOGNO T, DE PETROCELLIS L, MILONE A, DAVIS JB, AND FERNANDEZ-RUIZ JJ. Hypolocomotor effects in rats of capsaicin and two long chain capsaicin homologues. Eur J Pharmacol 420: 123131, 2001. DI MARZO V, MELCK D, BISOGNO T, AND DE PETROCELLIS L. Endocannabinoids: endogenous cannabinoid receptor ligands with neuromodulatory action. Trends Neurosci 21: 521528, 1998. DINH TP, CARPENTER D, LESLIE FM, FREUND TF, KATONA I, SENSI SL, KATHURIA S, AND PIOMELLI D. Brain monoglyceride lipase participating in endocannabinoid inactivation. Proc Natl Acad Sci USA 99: 10819 10824, EGERTOVA M AND ELPHICK MR. Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB. J Comp Neurol 422: 159 171, EGERTOVA M, GIANG DK, CRAVATT BF, AND ELPHICK MR. A new perspective on cannabinoid signalling: complementary localization of fatty acid amide hydrolase and the CB1 receptor in rat brain. Proc R Soc Lond B Biol Sci 265: 20812085, 1998. EMPTAGE N, BLISS TV, AND FINE A. Single synaptic events evoke NMDA receptor-mediated release of calcium from internal stores in hippocampal dendritic spines. Neuron 22: 115124, 1999. EVANS DM, JOHNSON MR, AND HOWLETT AC. Ca2 -dependent release from rat brain of cannabinoid receptor binding activity. J Neurochem 58: 780 782, EVANS DM, LAKE JT, JOHNSON MR, AND HOWLETT AC. Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization. J Pharmacol Exp Ther 268: 12711277, 1994. FACCI L, DAL TOSO R, ROMANELLO S, BURIANI A, SKAPER SD, AND LEON A. Mast cells express a peripheral cannabinoid receptor with dif prv. Mineral Metabolism Unit, Jerry L. Pettis Veterans Administration Medical Center K.-H. W.L., O.N., B.B., A.K.T., D.J.B. ; , Loma Linda, California 92357; and the Departments of Medicine and Biochemistry K.-H. W.L., D.J.B. ; and Ophthalmology K.H. ; , Loma Linda Uniuersity, Loma Linda, California 92354 ABSTRACT.
About West Midlands Development and Evaluation Service The West Midlands Development and Evaluation Service produce rapid systematic reviews about the effectiveness of healthcare interventions and technologies, in response to requests from West Midlands Health Authorities. Each review takes 3-6 months and aims to give a timely and accurate analysis of the available evidence, generating an economic analysis usually a cost-utility analysis ; of the intervention accompanied by a statement of the quality of the evidence. About InterDEC West Midlands DEC is part of a wider collaboration with three units in other Regions the Trent Working Group on Acute Purchasing, the Scottish Health Purchasing Information Centre and the Wessex Institute for Health Research and Development ; to share the work on reviewing the effectiveness and cost-effectiveness of clinical interventions. This group, "InterDEC", shares work, avoids duplication and improves the peer reviewing and quality control of these reports. Contributions of Authors Rachel Jordan undertook the research and production of the report, guided by Carole Cummins who also extracted data and made substantial comment on the content and presentation of the report. Amanda Burls helped refine the question and instigated the Dermatologists' Questionnaire, making comments on the final draft of the report before submission to external peer review.

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