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1. Allegro J.M.: The sacred mushroom and the cross. Doubleday, New York, 1970. 2. Allen J.W., Merlin M.D.: Psychoactive mushroom use in Koh Samui and Koh Pha-Ngan, Thailand. J. Ethnopharmacol., 1992, 35, 205228.
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Table 10 reports the estimated cost per 30 mg 30 ml for topical corticosteroids eligible for inclusion in this review, using prices listed in the BNF, March 2003 applying the largest pack size available ; . These costs are net costs and are subject to pharmacy handling costs e.g. a dispensing fee is estimated at 0.946 per item61 ; . There are wide variations in the cost of products available. Of note is the relatively high cost of the newer `oncedaily' topical corticosteroids, fluticasone propionate cream Cutivate ; and mometasone furoate Ellcon ; , at 4.59 and 4.88, respectively per 30 g 30 ml, with comparator potent products such as betametasone valerate Betnovate ; or hydrocortisone butyrate Locoid ; costing 1.31 and 2.07, respectively, per 30 g 30 Health Technology Assessment 2004; Vol. 8: No. 47 and glucotrol and elocon. Elocon pains among this cream 01 in in particular, it 01 cream.

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Three studies n 274 ; reported the axillary node dissection findings where the sentinel node was not identified, 17 53 32% ; of such cases had malignancy in the axilla. Of the 281 malignant cases in which the sentinel node was identified, the sentinel node was the only node positive for malignancy in 146 cases 52% ; . The included studies are largely from surgeons experienced in sentinel node biopsy no details given ; and the authors suggest that surgeons should demonstrate a false negative rate no greater than 5% before they consider using sentinel node biopsy over axillary dissection, 25 Grade III ; . The findings from an additional primary study are in line with those shown in the meta-analysis: the sentinel node was located in 64 79 81% ; patients, and its histology was the same as the axillary lymph node dissection in 63 cases 98.4% ; , and there was one false negative sentinel node biopsy where the axillary dissection showed malignancy.26 In the Italian study of women who chose sentinel node biopsy instead of routine axillary dissection, 379 sentinel node biopsies were performed 6 373 women had bilateral carcinoma ; .27 The sentinel node was negative in 285 biopsies, no dissection was performed and the 280 women concerned were followed-up quarterly with clinical examination of the axilla. At the time when a total of 343 years-at-risk were available for evaluation, no cases of clinically evident axillary node metastasis had occurred out of an expected seven. One woman developed a local breast recurrence and one developed distant metastatic bone disease. Ninety-four axillary dissections were performed because the sentinel node was positive, in 63 cases the sentinel node was the only positive node. From this series the authors concluded that sentinel biopsy should be the procedure of choice for staging axillary nodes in women with small-sized breast cancer and clinically negative nodes Grade VI ; . An observational study in the USA Grade VI ; reported data on a consecutive series of women with clinically negative nodes. Sixty-seven women were found to have negative sentinel nodes and, therefore, sentinel lymph node dissection was the only axillary procedure performed. Fifty-seven women who were found to have positive sentinel nodes went on to have axillary lymph node dissection 31 immediately and 26 in a second procedure ; . One woman in whom the lymph node mapping procedure was unsuccessful also underwent axillary node dissection.28 At a median follow-up of 39 months there were no local or axillary recurrences. Complications occurred in 20 58 women who underwent axillary lymph node dissection including seroma, wound infection, haematoma and chronic lymphoedema ; , and in 2 67 superficial cellulitis and seroma ; who had only sentinel lymph node dissection P 0.001 ; . 66. By whole body autoradiography , radioactivity was found in the placenta following administration of labeled drug to pregnant rats, but none was found in the fetuses, for instance, tacrolimus. Issue Evaluation has a long history within the Swiss Federal Office of Public Health SFOPH ; . In this presentation, we will describe the importance of planning the strategic use of evaluation findings from the very outset of programming a prevention intervention so that the findings will be taken into account in future developments. We describe procedures we use to support this process. Description Our service commissions external evaluation studies on behalf of our internal partners--the evaluation `purchasers'. We are responsible for their scientific quality and, more particularly, for assuring that the studies are designed and conducted to be of maximum utility. Scientific quality is a necessary but not sufficient condition for successful evaluation studies. We know that the technical evaluation reports are of interest to a limited readership: knowledge gained through evaluations is all too easily lost if the `right' information is not brought to the `right' audience `on time' and in the `right' way. We have to be creative to ensure that the important messages are highlighted and transmitted to a wide range of different stakeholders in a way that is appropriate to their particular needs. Politicians, civil servants, practitioners in the field, the research community, as well as members of the public are our stakeholders and, therefore, our potential evaluation `audiences'. 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