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Beta-Blocker Withdrawal The amlodipine component of CADUET is not a beta-blocker and therefore gives no protection against the dangers of abrupt beta-blocker withdrawal; any such withdrawal should be by gradual reduction of the dose of beta-blocker. Endocrine Function HMG-CoA reductase inhibitors, such as the atorvastatin component of CADUET interfere with cholesterol synthesis and theoretically might blunt adrenal and or gonadal steroid production. Clinical studies have shown that atorvastatin does not reduce basal plasma cortisol concentration or impair adrenal reserve. The effects of HMG-CoA reductase inhibitors on male fertility have not been studied in adequate numbers of patients. The effects, if any, on the pituitary-gonadal axis in premenopausal women are unknown. Caution should be exercised if an HMG-CoA reductase inhibitor is administered concomitantly with drugs that may decrease the levels or activity of endogenous steroid hormones, such as ketoconazole, spironolactone, and cimetidine. CNS Toxicity Studies with atorvastatin: Brain hemorrhage was seen in a female dog treated with atorvastatin calcium for 3 months at a dose equivalent to 120 mg atorvastatin kg day. Brain hemorrhage and optic nerve vacuolation were seen in another female dog that was sacrificed in moribund condition after 11 weeks of escalating doses of atorvastatin calcium equivalent to up to 280 mg atorvastatin kg day. The 120 mg kg dose of atorvastatin resulted in a systemic exposure approximately 16 times the human plasma area-under-thecurve AUC, 0-24 hours ; based on the maximum human dose of 80 mg day. A single tonic convulsion was seen in each of 2 male dogs one treated with atorvastatin calcium at a dose equivalent to 10 mg atorvastatin kg day and one at a dose equivalent to 120 mg atorvastatin kg day ; in a 2-year study. No CNS lesions have been observed in mice after chronic treatment for up to 2 years at doses of atorvastatin calcium equivalent to up to 400 mg atorvastatin kg day or in rats at doses equivalent to up to 100 mg atorvastatin kg day. These doses were 6 to 11 times mouse ; and 8 to 16 times rat ; the human AUC 0-24 ; based on the maximum recommended human dose of 80 mg atorvastatin day. CNS vascular lesions, characterized by perivascular hemorrhages, edema, and mononuclear cell infiltration of perivascular spaces, have been observed in dogs treated with other members of the HMG-CoA reductase class. A chemically similar drug in this class produced optic nerve degeneration Wallerian degeneration of retinogeniculate fibers ; in clinically normal dogs in a dose-dependent fashion at a dose that produced plasma drug levels about 30 times higher than the mean drug level in humans taking the highest recommended dose. 43 ; 20.12.2000 30 ; 17.06.1999 DE 19927616 54 ; Verfahren und Vorrichtung zur Unterscheidung zwischen elektromagnetischen Storsignalen und elektromedizinischen Abtastsignalen insbesondere von kardiologischen Implantaten A method and apparatus for discriminating between electromagnetic interference signals and electromedical sample signals, in particular from cardiological implants Procede et appareil pour discriminer entre des signaux d'interferences electromagnetiques et des signaux d'echantillonnages electromedicaux, en particulier venant d'implants cardiologiques 73 ; BIOTRONIK GmbH & Co. KG, Woermannkehre 1 and atomoxetine. TABLE 2. 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Being and high energy which may replace the effects of glutean induced exodorphins. The elimination of wheat, rice and corn based foods and their replacement with natural vegetables and fruits with a high antioxidant level and omega 3 fatty acids seems to restore balance. The rest of the diet is high in protein, which should be from healthy animals, chickens, pigs and beef. Animals raised or fattened in feedlots or which are mass produced in captivity are not healthy. They are raised as an industrial product which results in the animal's suffering from the same sort of mitochondrial cytopathology which causes chronic degenerative diseases in humans. They are obese and completely out of nutritional balance. Despite the relatively young age at which they are slaughtered, they frequently suffer from cancer, and other degenerative diseases. Flabby muscles make for tender meat. Beef is prized for human consumption by its tenderness and succulence, which means it contains a high fat content. Meat which is tender and well marbled with fat does not come from healthy steers. Chicken and pork are also penned in, force-fed food that is not healthy nutrition, given excessive antibiotics, hormones and other pharmaceuticals until their muscles are fat and flabby which in the industry is called tender and well marbled. The importance of meat in the human diet is emphasized by Eaton and Horner in their original article New England J. Med. 312: 293 1985 ; , thusly: "Paleolithic populations obtained their animal protein from wild game, especially gregarious ungulate herbivores, such as deer, bison, horses, and mammoths. The nutritional quality of such meat differs considerably from that of meat available in the modern American supermarket; the latter has much more fat -in subcutaneous tissue, in fascial planes, and as marbling within the muscle itself. Domesticated animals have always been fatter than their wild ancestors because of their steady food supply and reduced physical activity, but recent breeding and feeding practices have further increased the proportion of fat to satisfy our desire for.

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