Amlodipine
24. Kribbs SB, Merritt WM, Clair MJ, Krombach RS, Houck WV, Dodd MG, Mukherjee R, Spinale FG. Aml9dipine monotherapy, angiotensin-converting enzyme inhibition, and combination therapy with pacing-induced heart failure. Hypertension 1998; 31: 75565. Abernethy DR. Pharmacokinetics and pharmacodynamics of amlodipine. Cardiology 1992; 80 Suppl 1 ; : 316. 26. Faulkner JK, McGibney D, Chasseaud LF, Perry JL, Taylor IW. The pharmacokinetics of amlodipine in healthy volunteers after single intravenous and oral doses and after 14 repeated oral doses given once daily. Br J Clin Pharmac 1986; 22: 215. Abernethy DR, Gutkowska J. Winterbottom LM. Effects of amlodipine, a longacting dihydropyridine calcium antagonist in aging hypertension: pharmacodynamics in relation to disposition. Clin Pharmacol Ther 1990; 48: 7686. Faulkner JA, Hayden ML, Chasseaud LF, Taylor T. Absorption of amlodipine unaffected by food. Arzneim-Forsch Drug Res 1989; 39: 799801. Muller JE, Tofler GH, Stone PH. Circadian variation and triggers of onset of acute cardiovascular disease. Circulation 1989; 79: 73343. Quyyumi AA, Panza JA, Diodati JG, Lakatos E, Epstein SE. Circadian variation in ischemic treshold. A mechanism underlying the circadian variation in ischemic events. Circulation 1992; 86: 228. Millar-Craig MW, Bishop CN, Raftery EB. Circadian variation of blood pressure. Lancet 1978; I: 7957. 32. Raftery EB. Circadian variation in blood pressure: considerations for therapy. Postgrad Med J 1991; 67 Suppl 5 ; : 914. 33. Panza JA, Epstein SE, Quyyumi AA. Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N Engl J Med 1991; 325: 98690. Gould BA, Raftery EB. Twenty-four-hour blood pressure control: an intraarterial review. Chronobiol Int 1991; 8: 495505. Lemmer B, Scheidel B, Behne S. Chronopharmacokinetics and chronopharmacodynamics of cardiovascular active drugs. Propranolol, organic nitrates, nifedipine. Ann NY Acad Sci 1991; 618: 16691. Rudd P. Partial compliance: implications for clinical practice. J Cardiovasc Pharmacol 1993; 22 Suppl A ; : S1S5. 37. Taylor SH, Jackson J, Lee P Cocco G. A four-week double-blind, placebo, controlled, parallel dose-response study of amlodipine. Heart J 1989; 118: 11334. Thadani U. Amlodipine, a once-daily calcium antagonist in the treatment of angina pectoris a parallel dose-response, placebo-controlled study. Heart J 118: 1135. 39. Silke B, Verma SP, Zezulka AV, Sharma S, Reynolds G, Jackson NC, Guy S, Taylor SH. Haemodynamic and radionuclide effects of amlodipine in coronary artery disease. Br J Clin Pharmac 1990; 29: 43745. Bernink PJLM, de Weerd P ten Cate FJ, Remme WJ, Barth J, Enthoven R Haagen FDM, Holwerda NJ, Klomps HC. An 8-week double-blind study of amlodipine and diltiazem in patients with stable exertional angina pectoris. J Cardiovasc Pharmacol 1991; 17 Suppl 1 ; : S53S56. 41. Silke B, Goldhammer E, Sharma SK, Verma SP, Taylor SH. An exercise hemodynamic comparison of verapamil, diltiazem, and amlodipine in coronary artery disease. Cardiovasc Drugs Ther 1990; 4: 45764. DiBianco R, Schoomaker FW, Singh JB, Awan NA, Bennett T, Canosa FL, Kawanishi DT, Bamrah VS, Glasser SP Barry W. Aml9dipine combined with , beta blockade for chronic angina: results of a multicenter, placebo-controlled, randomized double-blind study. Clin Cardiol 1992; 15: 51924. Lehmann G, Reiniger G, Beyerle A, Rudolph W. Pharmacokinetics and additional anti-ischaemic effectiveness of amlodipine, a once-daily calcium antagonist, during acute and long-term therapy of stable angina pectoris in patients pre-treated with a beta-blocker. Eur Heart J 1993; 14: 15315. Meluzin J, Stejfa M, Novak M, Zeman K, Spinarova L, Julinek J, Toman J, Simek P. Amodipine in patients with stable angina pectoris treated with nitrates and beta-blockers. The influence on exercise tolerance, systolic and diastolic functions of the left ventricle. Int J Cardiol 1992; 37: 1019. Navarro Estrada JL, Oliveri R. Long-term efficacy of amlodipine in patients with severe coronary artery disease. J Cardiovasc Pharmacol 1993; 22 Suppl A ; : S24S28. 46. Chahine RA, Feldman RL, Giles TD, Nicod P Raizner AE, Weiss RJ, Vanov , SK. Randomized placebo-controlled trial of amlodipine in vasospastic angina. J Coll Cardiol 1993; 21: 136570. Deanfield JE, Detry JMRG, Lichtlen PR, Magnani B, Sellier P, Thaulow E. Qmlodipine reduces transient myocardial ischemia in patients with coronary artery disease: double-blind circadian anti-ischemia program in Europe CAPE trial ; . J Coll Crdiol 1994; 24: 14607. Frick MH, McGibney D, Tyler HM. Amlodipine: a double-blind evalution of the dose-response relationship in mild to moderate hypertension. J Cardiovasc Pharmacol 1988; 12 Suppl 7 ; : S76S78. 49. Mehta JL, Lopez LM, Vlachakis ND, Gradman AH, Nash DT, O'Connell MT, Garland WT, Pickering BI: Double-blind evaluation of the dose-response relationship of amlodipine in essential hypertension. Heart J 1993; 125: 170410. Heber ME, Brigden G, Al-Khawaja I, Raftery EB. Twenty-four hour blood pressure control with once daily calcium antagonist amlodipine. Br J Clin Pharmac 1989; 27: 35965. Gotzen R, Schulte KL, Grne RC. Effekt von Amlodipin auf das 24-hBlutdruckprofil bei Patienten mit essentieller Hypertonie. Herz Kreisl 1993; 25: 3269. Lund-Johansen P, Omvik P White W, Digranes O, Helland B, Jordal O, Stray , T. Long-term haemodynamic effects of amlodipine at rest and during exercise in essential hypertension. J Hypertens 1990; 8: 112936.
Address correspondence to: Dr. Jacques Turgeon, Faculte de Pharmacie, Universite de Montreal, C.P. 6128, Succursale Centre-Ville, Montreal, Quebec, Canada, H3C 3J7. E-mail: jacques.turgeon umontreal The laboratory of Dr. Jacques Turgeon is funded by the Canadian Institutes of Health Research, the Fonds de la Recherche en Sante du Quebec, and the Quebec Heart and Stroke Foundation. Article, publication date, and citation information can be found at : pharmrev etjournals . doi: 10.1124 pr.58.2.7. 244, for example, amlodipine benaz.
Conferences and Seminars Mouse Gene Mapping Workshop, The Jackson Laboratory, 46th Annual Short Course on Medical and Experimental Mammalian Genetics, Bar Harbor, Maine. [LBR] Mouse Gene Mapping, The Jackson Laboratory, 14th Annual Short Course on the Experimental Genetics of the Laboratory Mouse in Cancer Research, Bar Harbor, Maine. [LBR]. Generic Name 4.2 Cardiac Glycosides digoxin 5. BETA BLOCKERS 5.1 Alpha-Beta Blockers carvedilol labetalol 5.2 Cardioselective acebutolol atenolol atenolol chlorthalidone bisoprolol hydrochlorothiazide metoprolol 5.3 Noncardioselective nadolol pindolol propranolol oral solution is not covered ; propranolol suspended release 60mg only ; timolol 6. CALCIUM CHANNEL BLOCKERS 6.1 Dihydropyridines PA amlodipine ST felodipine suspended release ST isradipine ST isradipine suspended release nicardipine nifedipine nifedipine suspended release osmotic nifedipine suspended release nimodipine 6.2 Nondihydropyridines diltiazem diltiazem extended release ST diltiazem extended release verapamil verapamil suspended release 100mg, 200mg, 360mg caps are not covered ; verapamil suspended release. Sure readings were taken 24 hours after the dose. In both studies, the agents were the same, however, the dosing was varied slightly. In the first study, all agents were dosed once daily, amlodipine 2.5 mg, 5 mg, 10 mg ; , bisoprolol 5.25 mg HCTZ 2.5 mg, 5 mg, 10 mg ; , and enalapril 5 mg, 10 mg, 20 mg ; .5 In the second study, amlodipine A ; and bisoprolol 6.25 mg HCTZ Z ; were taken qd at the above-mentioned doses while enalapril E ; was administered 5 mg qd, 10 mg qd, 10 mg bid and 20 mg bid. A placebo P ; was also included in this study. 6 Table 1 ; References. The outer portion of the complete virion is a double-layered lipid membrane 16 which is punctuated by glycoprotein spikes 18. These glycoprotein spikes 18 are the means of attachment of this herpes virus to susceptible cells allowing entry and new infection of a previously uninfected cell. The human response, the immune system, responds to the antigenic stimulus of the structural proteins available to the human host by these glycoprotein spikes 18. Between the herpes virus bilayer 16 and the viral capsid 14 is an amorphous structure known as the tegument 20. This tegument 20 contains nonstructural proteins which are necessary for multiplication of the virus. It contains a number of viral enzymes and factors necessary for viral assembly. A complete herpes virus virion 10 is depicted in FIG. 1d. Antibodies to structural glycoprotein, for instance gB and gH of human cytomegalovirus, are produced. In the case of incomplete virus replication, the herpes virus genome is partially opened and producing some proteins. These aberrant proteins are not wanted in the healthy cellular matrix and efforts to rid the matrix of these partial viral gene products is made by the process of exocytosis. By this process of exocytosis, nonstructural gene products e.g. UL44 and UL57 ; reach the extracellular space and are thus available to the human host immune system so that specific antibodies may be produced to these nonstructural gene products, UL44 and UL57. These nonstructural gene products are behind the virus bilayer 16 and are not exposed to antibody production when whole complete virus multiplication occurs. There is evidence that supports the theory that both HCMV and EBV are cardiotropic for the human myocyte. Based on our research, it is believed that the human cardiac myofiber, like the B-lymphocyte for EBV and the mononuclear progenitor cell for HCMV, is a site of non-infectious episome-mediated persistent infection. This is different from the human epithelial cell of the pharynx which produces mainly whole infectious EBV virus. HCMV immediate-early gene transcripts have been detected in the heart by in-situ hybridization techniques in patients with HIV-associated cardiomyopathy. Likewise, the EBV genome was detected by polymerase chain reaction amplification of DNA extracted from the heart at autopsy. An intense mononuclear cell infiltrate in the myocardium consisted essentially of T-cells without identifiable B-cells. This inflammatory response is the result of complete virus multiplication. Accordingly, our research has indicated that CFS is a non-permissive, persistent herpes virus infection of the heart, wherein EBV and or HCMV nucleic acids are present in the hearts of CFS patients. This hypothesis was generated based in part upon endomyocardial biopsies of patients with CFS. HCMV nucleic acids by polymerase chain reaction have been found in biopsies of the heart from CFS patients. The research conducted revealed that all CFS patients have abnormal oscillating T-wave flattenings and T-wave inversions detectable from 24-hour electrocardiographic Holter ; monitoring. An initial 24-hour electrocardiographic T-wave study compared CFS patients to random non-CFS patients, from an internal medicine practice, wherein both patient groups were restricted to an age less than 50 years old to minimize the occurrence of chronic diseases in both populations. Notably, chronic diseases such as hypertensive and amoxycillin. A-200.58, 95 Abilify.13, 24, 76 Abrasive Cleanser.21, 93 Accolate.68, 91 Acetaminophen .21, 73 Acetaminophen Codeine.21, 73 Acetaminophen Hydrocodone.21, 73 Acetasol.21, 92 acetaZOLAMIDE .21, 71 Acetic Acid.21, 92 Acetic Acid Aluminum Acetate .21, 92 Acetic Acid Hydrocortisone Propylene Glycol Sodium Acetate Benzethonium .21, 92 Acetylcysteine .21, 70, 91 Achromycin .63, 86 Actifed .66, 70, 90 Activated Charcoal .22, 70, 83 Actonel .59, 80 Actos .55, 69 Acyclovir .22, 87, 94 Adapalene .22, 93 Adapin .14, 36, 75 Adderall .16, 24, 76 Adderall XR .16, 24, 76 Adenocard .22, 72 Adenosine .22, 72 Adrenalin .36, 73 Afrin .53, 93 AK-Con.51, 92 Akineton .27, 79 Albuterol .22, 90 Alcaine.57, 92 Aldactazide.62, 71 Aldactone .62, 71 Aldomet .48, 73 Alendronate .22, 80 Allbee with C .67, 89 Allegra .38, 70, 90 Allegra-D .39, 70, 90 Allercreme .36, 95 Allergen .24, 92 Allopurinol.22, 80 Alora .37, 79 Alphagan .27, 91 Alprazolam .17, 22, 75, Aludrox .23, 81 Aluminum Acetate .22, 95 Aluminum Hydroxide .22, 81 Aluminum Hydroxide Magnesium Hydroxide.23, 81 Aluminum Hydroxide Magnesium Hydroxide Simethicone.23, 81 Aluminum Hydroxide Magnesium Trisilicate.22, 81 Alupent .47, 90 Amantadine. 23, 79, 87 Ambien. 17, 68, 77 Amikacin . 23, 86 Amikin . 23, 86 Amino Acid Injection . 23, 88 Aminophylline. 23, 90 Aminosyn . 23, 88 Amitriptyline . 14, 23, 75 Amlodipinee . 23, 72 Amobarbital. 17, 18, 23, Amoxapine . 14, 23, 76 Amoxicillin . 23, 85 Amoxicillin Clavulanate. 24, 85 Amoxil . 23, 85 Amphetamine Mixture. 16, 24, 76 Amphojel . 22, 81 Ampicillin. 24, 85 Amytal . 17, 18, 23, Anafranil. 16, 31, 75 Ancef. 29, 86 Androlan. 63, 80 Antabuse. 35, 70 Antilirium . 55, 70 Antiminth . 58, 87 Antipyrine Benzocaine . 24, 92 Antivert. 47, 74, 83 Anusol . 59, 83 Anusol-HC. 59, 83 Apresoline . 42, 73 Aquaphor . 36, 95 Aquasol A. 67, 89 Aquasol E. 68, 89 Aralen. 29, 87 Aricept. 35, 79 Aripiprazole . 13, 24, 76 Aristocort. 65, 80, 95 Artane . 66, 79 Asacol . 47, 83 Ascorbic Acid . 24, 89 Asendin . 14, 23, 76 Aspirin . 24, 70, 73 Atarax. 17, 42, 70, Atenolol . 24, 72, 79 Ativan . 17, 46, 75, Atomoxetine . 24, 76 Atorvastatin . 24, 72 Atropine Sulfate . 25, 91 Atrovent. 43, 91 Attapulgite . 25, 82 Augmentin. 24, 85 Auralgan. 24, 92 Avage. 62, 94 Avandia . 60, 69. The active ingredient in norvasc is 2 4- 2-chlorophenyl ; 4- dihydropyridine, which is a commonly referred to as amlodipine, and which is a member of a class of compounds known as dihyrdopyridines and clavulanate. Aclovate is a medication used to treat swelling, inflammation, or itching of skin conditions such as eczema, dermatitis, rashes, insect bites, poison ivy. Brand Name Strength Dosage Form ALL ALL ALL Brand NDCs removed from formulary. Generic substitution required. Daily dose limit of #1 day Removed from formulary Removed from formulary Removed from formulary Removed from formulary Daily dose limit of #1 day Daily dose limit of #1 day, except 30mg, limited to #2 day. Removed from formulary Add to formulary for patients already titrated on both benazepril and amlodipine Contingent therapy set-up if patient utilization shows individual titration on benazepril and amlodipine. Only immediate release removed Committee Actions Brand NDCs removed from formulary. Generic substitution required. Removed from formulary Daily dose limit of #1 day ALL Comments and ampicillin. 1. Ary, M., Cox, B. & Lomax, P. 1977 ; J. Pharmacol. Exp. Ther. 200, 271-276. 2. Lal, H. 197'M ; Life Sci. 17, 483-496. 3. Cox, B., Ary, M & Lomax, P. 1976 ; Life Sci. 17, 41-42. 4. Walter, R., Ritzmann, R., Bhargava, H., Rainbow, T., Flexner, L. & Krivoy, W. 1978 ; Proc. Natl. Acad. Sci. USA 75, 45734576. 5. Walter, R., Ritzmann, R., Bhargava, H. & Flexner, L. 1979 ; Proc. Generic for norvasc amlodipineMorning Session 1 Topic: Neuromuscular, eye & stroke disorders Chairman: Professor DW Chadwick 0900 6 Carotid stenting techniques have evolved since CAVATAS, but have they had an impact on peri-operative morbidity? Does the Sheffield stenting register provide a clue? Randall M The Third International Stroke Trial IST-3 ; . Thrombolysis for acute ischaemic stroke Kane I Neuromyelitis optica in the United Kingdom Jacob A Limb girdle muscular dystrophy type 21 Lecky B Facial involvement in MuSK antibody positive myasthenia gravis Farrugia M Treating the untreatable: exercise-induced stem cell activation as a novel treatment for mitochondrial myopathy Schaefer A Falls in myotonic dystrophy Wiles M Coffee. Takeda pharma gmbh exhibition booth at a medical congress and arava.
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HID Rank 1 Agent Amlodipine Norvasc ; Justification With indications for hypertension, chronic stable angina, and vasospastic angina, smlodipine is the most utilized calcium channel blocker in the Mississippi Medicaid population. This dihydropyridine CCB is not available generically and is currently preferred. Available generically in immediate and sustained release formulations, diltiazem is a commonly used benzothiazepine CCB. This agent is approved for hypertension, chronic stable angina, and vasospastic angina. Generic formulations of diltiazem are currently preferred and are recommended for continued inclusion on the PDL. Single source branded formulations of diltiazem are not recommended for PDL inclusion. Felodipine is approved for the treatment of hypertension. This agent, a dihydropyridine CCB, is currently preferred and is recommended for continued inclusion on the PDL. Nicardipine is a dihydropyridine CCB indicated for hypertension and chronic stable angina. This agent is available in immediate-release, as well as sustained-release formulations. Nicardipine is currently preferred. Nifedipine is a dihydropyridine CCB approved for the treatment of hypertension, chronic stable angina, and vasospastic angina. This agent is available generically and is currently preferred. Verapamil is a diphenylalkylamine CCB available in several different formulations. This agent is indicated for hypertension, chronic stable angina, vasospastic angina, and prophylaxis of repetitive PSVT. Generic formulations of verapamil are currently preferred and are recommended for continued inclusion on the PDL. Single source branded formulations of verapamil are not recommended for PDL inclusion. A brand-only dihydropyridine CCB, isradipine is indicated for hypertension only. This agent is currently non-preferred. A brand-only dihydropyridine CCB, nisoldipine is indicated for hypertension only. This agent is currently non-preferred. Table 7. Outcomes Evidence for Single Entity Mineralocorticoid Aldosterone ; Receptor Antagonists Efficacy Study Study Design Variables Results Hypertension Primary: mean Mean changes in DBP and systolic blood pressure Flack et al.24 Randomized, change in SBP ; from baseline to final visit were significantly double-blind, diastolic blood greater with eplerenone treatment than with placebo Eplerenone 50 placebo and pressure DBP ; or losartan treatment in all patients combined p mg day, losartan 50 activefrom baseline to 0.001 ; and in black patients p 0.001 ; . mg day or placebo controlled, once daily, doses placebo run-in, the final visit were increased if parallel group Adjusted mean changes in DBP and SBP were blood pressure significantly greater with eplerenone treatment than remained N 535 with placebo p 0.001 ; , but not significantly uncontrolled different between eplerenone and losartan p 16 weeks 0.068 ; in white patients. There were no significant differences in the incidence of adverse events noted between eplerenone, placebo or losartan. The reported incidence of gynecomastia, breast pain, menstrual abnormalities, impotence, and decreased libido with eplerenone was low and comparable to losartan and placebo. SBP response to eplerenone and amlodipind was essentially identical. Symptom distress technique to assess the influence of drug treatment on quality of life ; index was assessed and results favored eplerenone vs. amlodipine p 0.03 ; . Patients with symptom distress showed a decrease of psychosocial measures of quality of life p 0.001 ; . SF-36 Health Survey showed no significant treatment effect between the two treatments. Multicenter, placebo run-in, double-blind, randomized, placebocontrolled, parallel-group study N 341 8 weeks Primary: mean change from baseline of trough cuff seated DBP and SBP at week 8 There were significant differences in mean change of SBP with the eplerenone and ACE vs. placebo and ACE group p 0.05 ; and eplerenone and ARB vs. placebo and ARB groups p 0.05 ; . There were significant differences in mean change of DBP with eplerenone and ARB group vs. placebo and ARB group p 0.05 ; . There were no significant differences in DBP with the eplerenone and ACE group vs. placebo and ACE group and azithromycin. DATA FIELD DESCRIPTIONS Country: The name of the country whose data is stored in this table. Region: The Geographical region in which this country belongs. Priority: The UNFPA priority rating for this country. LDC: The Least Developed Country status. Country Population: The total people count. Female Population The total female count. Female Age 15 to 49 Percent: The percent of females of reproductive age. ACKNOWLEDGMENTS We thank Gordon Wong Genetics Institute, Cambridge, Mass. ; and Steven Dower Immunex Corp., Seattle, Wash. ; for providing human recombinant IL-6 and IL-1, respectively, Karen R. Prowse, Jean J. Latimer, Kwang-Ai Won, Karen Morella, and Gerald P. Jahreis for technical assistance or advice, and Marcia Held for secretarial work. This work is part of a collaborative interaction with the laboratory of Ljiliana Sevaljevic, Institute for Biological Research, University of Belgrade, Yugoslavia, supported by a grant of the Fogerty International Center. This study was supported by Public Health Service grant CA26122 from the National Cancer Institute. H.B. is a recipient of an established investigatorship award from the American Heart Association. The adverse experiences that occurred in placebo-controlled clinical trials in at least 2% of patients treated with exforge but at a higher incidence in amlodipine valsartan patients n 1, 437 ; than placebo n 337 ; included peripheral edema 4% vs 0% ; , nasopharyngitis 3% vs 8% ; , upper respiratory tract infection 9% vs 1% ; and dizziness 1% vs 9. 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ETRs - Entity Types Referenced. Normally an ETR is a table in the RDBMS context and a Record type in the flat file context. Input DETs - Data Element Types - Input to the Logical Transaction being entered Output DETs - Data Element Types - Output by the Logical Transaction being entered TCAF - Technical Complexity Adjustment Factor - computed value of the factors in the TCAF Tab MK II FPI Adjusted ; - this is the software size expressed as Function Point Index Productivity FPI PD - Number of FPI that can be produced in one Person Day PD ; . Please note that this includes all phases of software development including Quality Assurance activities and amoxycillin. Avoided. The inhibiting effects of anticholinergic drugs on gastric hydrochloric acid secretion are antagonized by agents used to treat achlorhydria and those to test gastric secretion. 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