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Study design and patients. Study design, selection criteria and review procedures for assessment of end points have been described previously 7 ; . In brief, 948 patients who underwent elective CABG with saphenous vein grafts for disabling angina were entered into the trial by 10 participating centers between July 1987 and August 1990. Of these, 494 56 women and 438 men ; received internal mammary artery IMA ; grafts in addition to vein grafts. Exclusion criteria included age 70 years, unstable angina 2 days or MI 7 days before the operation, previous or concurrent cardiac surgery, impaired renal or hepatic function, concomitant severe disease and the inability to repeat coronary angiography owing to allergy to a contrast agent. Written, informed consent from all patients was obtained. The protocol was approved by the Ethics Committee of each participating hospital. Patients were assigned randomly to treatment with aspirin, aspirin plus dipyridamole or oral anticoagulant agents acenocoumarol or phenoprocoumon ; for at least one year after the operation. They were stratified per center. Saphenous vein and IMA grafts were implanted according to the routine techniques of each participating hospital. The decision to use IMA grafts was made by the surgeon. The lumen of the grafted coronary artery was measured by calibrated probes at the arteriotomy site and as distal as possible. Coronary endarterectomy was performed. Capillary LC, 1.25 pg injected, for instance, warfarin. 5375 Mira Sorrento Place, Suite 100 San Diego, CA 92121 858 ; 622-0900 telephone reliantlaser Reliant is introducing the revolutionary FraxelTM SR Laser that treats aging and sun damaged skin with patterns of microthermal zones. Fraxel Laser Treatment spares surrounding healthy tissue resulting in rapid re-epithelialization and minimization of side effects.

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82. Poggesi L, Scarti L, Boddi M, Masotti G, Serneri GG. Pentoxifylline treatment in patients with occlusive peripheral arterial disease: circulatory changes and effects on prostaglandin synthesis. Angiology. 1985; 36: 628-637. Pignoli P, Ciccolo F, Villa V, Longo T. Comparative evaluation of buflomedil and pentoxiphylline in patients with peripheral arterial occlusive disease. Curr Ther Res. 1985; 37: 596-606. Chacon-Quevedo A, Eguaras MG, Calleja F, et al. Comparative evaluation of pentoxifylline, buflomedil, and nifedipine in the treatment of intermittent claudication of the lower limbs. Angiology. 1994; 45: 647-653. Perhoniemi V, Salmenkivi K, Sundberg S, Johnsson R, Gordin A. Effects of flunarizine and pentoxifylline on walking distance and blood rheology in claudication. Angiology. 1984; 35: 366-372. Feine-Haake G. Assessment of the therapeutic efficacy of pentoxifylline Trental ; : a double-blind trial in geriatric patients with vascular disorder. Pharmatherapeutica. 1983; 3 suppl 1 ; : 46-51. 87. Accetto B. Beneficial hemorheologic therapy of chronic peripheral arterial disorders with pentoxifylline: results of a double-blind study versus vasodilator-nylidrin. Heart J. 1982; 103: 864-869. Trubestein G, Trubestein R, Duong QD. Com parative evaluation of the effectiveness of buflomedil and pentoxiphylline in patients with arterial occlusive disease. Angiology. 1981; 32: 705-709. Mashiah A, Patel P, Schraibman IG, Charlesworth D. Drug therapy in intermittent claudication: an objective assessment of the effects of three drugs in patients with intermittent claudication. Br J Surg. 1978; 65: 342-345. Deutschinoff A, Grozdinsky L. Rheological and anticoagulant therapy of patients with chronic peripheral occlusive arterial disease COAD ; . Angiology. 1987; 38: 351-358. Dettori AG, Pini M, Moratti A, et al. Acenovoumarol and pentoxifylline in intermittent claudication: a controlled clinical study. Angiology. 1989; 40: 237-248. Ernst E, Kollar L, Resch KL. Does pentoxifylline prolong the walking distance in exercised claudicants? a placebo-controlled double-blind trial. Angiology. 1992; 43: 121-125. Lindgarde F, Jelnes R, Bjorkman H, et al. Con servative drug treatment in patients with mod.

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The GDG noted that the use of low adjusted-dose anticoagulation with acenocoumarol in combination with the antiplatelet triflusal was more effective than conventional adjusted-dose anticoagulation with acenocoumarol alone for the prevention of stroke 173 ; . It is unclear whether similar results apply to anticoagulation with warfarin instead of acenocoumarol or other antiplatelet agents. The GDG noted that Trifusal is not used in the UK, and that previous studies of warfarin and aspirin combination therapy have been less effective or had more adverse effects than with warfarin alone. Therefore the GDG did not make any recommendations in this area. 11.2.4. Recommendations. The exclusions for Medicare Part D are drugs that are also excluded from Medicaid coverage with the exception of smoking cessation. The drugs or classes that are currently restricted are: Agents used for weight loss Agents used for weight gain including cancer and HIV ; Agents used to promote fertility Agents used for cosmetic purposes Agents that promote hair growth Agents used for symptomatic relief of cough and colds Prescription vitamins and mineral products except prenatal vitamins and fluoride preparations ; Nonprescription drugs OTC drugs ; Outpatient drugs where the manufacturer requires associated tests or monitoring services be purchased from the manufacturer or its designee as a condition of sale Barbiturates Benzodiazepines There are 13 categories of drugs for which separate payment is made under Medicare Part B 2 ; . These drugs include: Drugs furnished incident to a physician's service Separately billable end stage renal disease drugs in patients undergoing dialysis Osteoporosis drugs provided by home health agencies under certain conditions Drugs used in immunosuppressive therapy for a transplant covered under Medicare Parenteral nutrition for individuals with a nonfunctioning digestive tract Infusable Durable Medical Equipment DME ; supply drugs Intravenous immune globulin IVIG ; provided in the home for individuals with a diagnosis of primary immune deficiency Certain oral chemotherapy agents used in cancer treatment for which there is an infusible version of the drug and have a medically accepted indication Oral anti-emetics used in cancer treatment as a FULL replacement for intravenous treatment Hepatitis B vaccine for individuals at high or intermediate risk of contracting hepatitis B Inhalation DME supply drugs when a nebulizer has been provided by Medicare and calciferol.
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TABLE 3 Surface charge density r ; and membrane permeability due to the "leak" K + and Na + transport P ; obtained from fits of Eq. 6 to the K + and Na + influxes as well as effluxes cf. inset of Fig. 1 ; K + influx K + efflux Na + influx Na + efflux.

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