Miconazole
Just remember that everything sounds bad on the net because the drug companies have to put out every single tiny miniscule thing that might go wrong.
1435003 1436006 1437009 Methylprednisolone 200 mg ; Methylprednisolone Acetate 200 mg ; Methylprednisolone Hemisuccinate 200 mg ; Methyl Salicylate 2 mL ; AS ; Methyl Stearate 300 mg ; Methyltestosterone CIII 200 mg ; Methysergide Maleate 200 mg ; Metoclopramide Hydrochloride 500 mg ; Metocurine Iodide 300 mg ; Metolazone 200 mg ; Metoprolol Related Compound A 20 mg ; + - ; 1- ethylamino ; 3-[4- 2-methoxyethyl ; phenoxy]-propan-2-ol ; Metoprolol Related Compound B 50 mg ; + - ; 1-Chloro-2hydroxy-3-[4- 2-methoxyethyl ; phenoxy]-propane ; Metoprolol Related Compound C 20 mg ; + - ; 4-[2-Hydroxy3- 1-methylethyl ; aminopropoxy]benzaldehyde ; Metoprolol Related Compound D 50 mg ; + - ; N, N-bis-[2hydroxy-3-[4- 2-methoxyethyl ; phenoxy]propyl] 1methylethyl ; amine ; Metoprolol Fumarate 200 mg ; Metoprolol Succinate 200 mg ; Metoprolol Tartrate 200 mg ; Metrizamide 500 mg ; Metronidazole 100 mg ; Metyrapone 200 mg ; Metyrosine 200 mg ; Mexiletine Hydrochloride 200 mg ; Mezlocillin Sodium 350 mg ; Imconazole 200 mg ; Miconazoke Nitrate 200 mg ; Powdered Milk Thistle Extract 250 mg ; Milrinone 500 mg ; Milrinone Related Compound A 50 mg ; 1, 6-Dihydro-2methyl-6-oxo 3, ; -5-carboxamide ; Minocycline Hydrochloride 200 mg ; Minoxidil 125 mg ; Mirtazapine 350 mg ; Mitomycin 50 mg ; Mitotane 500 mg ; Mitoxantrone Hydrochloride 400 mg ; Mitoxantrone System Suitability Mixture 0.3 mg ; Molindone Hydrochloride 500 mg ; Mometasone Furoate 200 mg ; Monensin Sodium 200 mg ; Monobenzone 200 mg ; Mono- and Di-acetylated Monoglycerides 200 mg ; Monoglycerides 125 mg.
Under the leadership of three English neurologists--John Hughlings Jackson, Russell Reynolds, and Sir William Richard Gowers--the modern medical era of epilepsy begins. In a study, Jackson defines a seizure as "an occasional, an excessive, and a disorderly discharge of nerve tissue on muscles." He also recognizes that seizures can alter consciousness, sensation, and behavior. 10. DRUG INTERACTIONS Changes in Contraceptive Effectiveness Associated with Co-Administration of Other Drugs Contraceptive effectiveness may be reduced when hormonal contraceptives are co-administered with some antifungals, anticonvulsants, and other drugs that increase metabolism of contraceptive steroids. This could result in unintended pregnancy or breakthrough bleeding. Examples include barbiturates, griseofulvin, rifampin, phenylbutazone, phenytoin, carbamazepine, felbamate, oxcarbazepine, topiramate, and modafinil. Women may need to use an additional contraceptive method when taking such medications. Several of the anti-HIV protease inhibitors have been studied with co-administration of oral combination hormonal contraceptives; significant changes increases and decreases ; in the mean AUC of the estrogen and progestin have been noted in some cases. The efficacy and safety of oral contraceptive products may be affected; it is unknown whether this applies to NuvaRing. Healthcare providers should refer to the label of the individual anti-HIV protease inhibitors for further drug-drug interaction information. Herbal products containing St. John's Wort hypericum perforatum ; may induce hepatic enzymes cytochrome P450 ; and p-glycoprotein transporter and may reduce the effectiveness of contraceptive steroids. This may also result in breakthrough bleeding. Increase in Plasma Hormone Levels Associated with Co-Administered Drugs Co-administration of atorvastatin and certain oral contraceptives containing ethinyl estradiol increase AUC values for ethinyl estradiol by approximately 20%. Ascorbic acid and acetaminophen may increase plasma ethinyl estradiol levels, possibly by inhibition of conjugation. CYP 3A4 inhibitors such as itraconazole or ketoconazole may increase plasma hormone levels. Co-administration of vaginal miconazole nitrate and NuvaRing increases the serum concentrations of etonogestrel and ethinyl estradiol by up to 40%. Changes in Plasma Levels of Co-Administered Drugs Combination hormonal contraceptives containing some synthetic estrogens e.g., ethinyl estradiol ; may inhibit the metabolism of other compounds. Increased plasma concentrations of cyclosporine, prednisolone, and theophylline have been reported with concomitant administration of oral contraceptives. In addition, oral contraceptives may induce the conjugation of other compounds. Decreased plasma concentrations of acetaminophen and increased clearance of temazepam, salicylic acid, morphine and clofibric acid have been noted when these drugs were administered with oral contraceptives. 11. INTERACTIONS WITH LABORATORY TESTS Certain endocrine and liver function tests and blood components may be affected by combined hormonal contraceptives: a. Increased prothrombin and factors VII, VIII, IX and X; decreased antithrombin 3, increased norepinephrine-induced platelet aggregability. b. Increased thyroid-binding globulin TBG ; leading to increased circulating total thyroid hormone, as measured by protein-bound iodine PBI ; , T4 by column or by radioimmunoassay. Free T3 resin uptake is decreased, reflecting the elevated TBG; free T4 concentration is unaltered. c. Other binding proteins may be elevated in serum. Cash, cash equivalents, and marketable securities at the end of 2006 are expected to be approximately $4 million to $6 million. The analysis of the data revealed that one in every 50 people taking the two drugs would require hospital admission on account of heart failure and mirtazapine. Most infections respond well to these topical agents, which include: miconazole micatin, monistat-derm ; clotrimazole lotrimin af ; if jock itch is severe or doesn't respond to over-the-counter medicine, you may need a prescription-strength topical or oral medication. Ketoconazole and Miconaozle Are hGR Antagonists hepatocyte preparation. No information on the patients was available to us, apart from age and sex and the reason for surgery. It is noteworthy that pathological examination of the surgical specimen was in no way hindered by the procedure used to obtain primary hepatocytes; the tissues used for this study would otherwise have been immediately discarded. In all patients, viral serological analysis hepatitis B and C viruses and human immunodeficiency virus ; was negative. Primary human hepatocytes were prepared and cultured as described previously Pichard-Garcia et al., 2002 ; . The cells were plated into collagen-coated dishes at 1.7 105 cells cm2 in a hormonally and chemically defined medium consisting of a mixture of William's E and Ham's F-12 [1: 1 v v ; Forty-eight hours after plating, cells were cultured in the presence or absence of the indicated inducers for 24 h. Cell Culture and Transfection. HepG2 and HeLa cell lines were obtained from the European Collection of Cell Cultures Salisbury, UK ; and maintained in Dulbecco's modified Eagle's medium supplemented with 10% fetal calf serum, 1 mM glutamine, 10 mM sodium pyruvate, and 100 g ml penicillin and streptomycin. The stably transfected cell line HLMN was obtained by transfecting HeLa cells with the glucocorticoid-responsive reporter gene mouse mammary tumor virus MMTV ; -LUC-SVNeo as described previously Balaguer et al., 1999; Dvorak et al., 2003 ; . The pSG5-hGR, pSG5hPXR, pBSEN-hCAR, pGL3 CYP3A4 XREM-7800-7200 -262 11 ; LUC, pTAT- GRE ; 2-TK-LUC, and pGL3-CAR 4711 144 ; -LUC have been described previously Pascussi et al., 2001; Gerbal-Chaloin et al., 2002; Pascussi et al., 2003 ; . For reporter assays, 6 105 HepG2 or HeLa cells were transiently transfected with 10 ng of expression plasmid pSG5-hGR, pSG5-hPXR ; or 100 ng of pBSENhCAR together with 100 ng of luciferase reporter constructs pGL3CAR 4711 144 ; -LUC or pGL3 CYP3A4 XREM-7800-7200 262 11 ; -LUC and 50 ng of pSV Galactosidase expression plasmid for transfection quality control. After 16 h of serum starvation, HepG2 cells transfected with pSG5-hGR and pGL3-CAR 4711 144 ; -LUC and stably transfected HMLN cell lines were treated with ketoconazole for 1 h before 0.1 M dexamethasone treatment for 3 h. After 24 h, HepG2 cells transfected with pGL3 CYP3A4 XREM-7800-7200 262 11 ; -LUC and pSG5-hPXR or pBSEN-hCAR expression vectors were treated with ketoconazole and rifampicine or ketoconazole alone, respectively, for 24 h and luciferase activity was measured. Total RNA Purification, Northern Blot, and Ribonuclease Protection Assays. Total RNA was isolated using TRIzol reagent Invitrogen ; . Twenty-five micrograms of total RNA was analyzed by Northern blot using [ -32P]dCTP-labeled rat glyceraldehyde-3-phosphate dehydrogenase cDNA probe for quality control or analyzed with human TAT or CYP1A1 complementary cDNA probes GerbalChaloin et al., 2006 ; . For ribonuclease protection assays, 25 g of total RNA was analyzed using specific RNA probes directed against PXR and CAR as described previously Gerbal-Chaloin et al., 2002 ; . Quantitative-Polymerase Chain Reaction. cDNA was synthesized from 1 g of total RNA using Moloney murine leukemia virus reverse transcriptase Invitrogen ; at 37C for 50 min in the presence of random hexamers. One-tenth was used for quantitative-PCR amplification using the Light Cycler apparatus Roche Diagnostics, Meylan, France ; . The following program was used: an activation step at 95C for 8 min was followed by 45 cycles of PCR denaturation at 95C for 15 s; annealing of 10 s 65C for CAR, PXR, CYP3A4, CYP2C9, and CYP2B6 or 70C for the others; and elongation at 72C for 10 s ; . Primers are shown in Table 1. The expression of -actin was used for relative quantification. The calibration standard curves were generated using three 10-fold serial dilutions of the reverse transcription samples prepared from human liver tissue. The measurements were performed in duplicate, and all the primers were located in two different exons except for UGT1A1 Assenat et al., 2004 ; . Primers for CYP3A4, CYP2B6, and CYP2C9 have been designed specifically for these isoforms and do not recognize CYP3A5, CYP2B7, or CYP2C8 18 19, respectively. Moreover, we verified after each run of RT-PCR that the melting curve of the and monistat. Phenylephrine, Nw-nitro-L-arginine L-NA ; , and inorganic salts purchased from Sigma were dissolved in water. Indomethacin and miconazole Sigma ; were dissolved in 4.2% NaHCO3 and ethanol, respectively. Sodium arachidonate NuChek ; was dissolved in distilled water, divided into 1 mg mL aliquots, and stored under N2 at 70C. What is the difference between miconazole and clotrimazole
Im on alot of medication still having problems and i have been given the option of having surgery where they remove this scar and possibley become seizure free i would appreciate any advice or comments from anyone who knows about this or has been through it.
John robbins: percentage of cancer patients whose lives are predictably saved by chemotherapy - 3% conclusive evidence majority of cancers ; that chemotherapy has any positive influence on survival or quality of life - none and nizoral. Itraconazole. * SPORANOX miconazole-zinc oxide-white petroleum. VUSION L ; posaconazole. NOXAFIL PA ; L ; terbinafine HCL. LAMISIL L ; voriconazole. VFEND L and ovral. Leuprolide acetate [INJ] lev pse gg LEVAQUIN LEVATOL LEVEMIR vial only [INJ] LEVITRA LEVO-DROMORAN inj levobunolol hcl levocarnitine levora-28 levorphanol tartrate levothroid levothyroxine sodium LEVOXYL LEVSIN inj LEXAPRO LEXIVA LIBRIUM inj lidazone hc lidocaine hcl dental mucous membrn products, gel, lotion, oint lidocaine hcl inj 0.5 %, 1 %, 1.5 %, 2 %, 4 %, 10 mg ml, 20 % lidocaine hcl inj 10 % LIDOCAINE HCL inj 2 % lidocaine hcl in 7.5% dextrose, hcl w-epinephrine, hcl w epinephrine, hcl-epinedphrine [INJ] lidocaine hcl viscous lidocaine, -hc, -prilocaine LIDODERM lincoject [INJ] LINDANE LIORESAL, INTRATHECAL [INJ] LIPOSYN II, III [INJ] lipram, -cr liquibid 1200 liquicough dm soln 175 mg liquicough hc lisinopril, -hctz lithium carbonate, citrate LIVER [INJ] LIVER, IRON & VITAMINS [INJ] LODOSYN lohist 12d, 12hr lohist-d lohist-lq lohist-pd lonox loperamide hcl lorazepam LORAZEPAM INTENSOL LOTEMAX LOTREL * LOTRONEX lovastatin LOVENOX [INJ] low-ogestrel loxapine, succinate LOZI-FLUR lugol's LUMIGAN LUMINAL SODIUM [INJ] LUPRON DEPOT inj 3.75 mg ml, 11.25 mg ml[INJ] LUPRON DEPOT-PED [INJ] lutera lypholyte, -ii [INJ] LYSIPLEX syrup LYSODREN m-clear, jr m-end, dm, max M-M-R II VACCINE W DILUENT [INJ] M-R-VAX II VACCINE W DILUENT [INJ] M.V.I. 12, PEDIATRIC [INJ] m.v.i. adult [INJ] MACUGEN [INJ] magnesium chloride [INJ] magnesium sulfate inj 4 %, 50 %[INJ] MAGNESIUM SULFATE inj 50 %[INJ] MAGNESIUM SULFATE IN DEXTROSE [INJ] MAGNEVIST [INJ] MALARONE maldemar manganese, chloride, sulfate, trace element [INJ] mannitol [INJ] maprotiline hcl marcof margesic, h marlexate marten-tab MARTINIC MASK SET, W Y-PIECE maternity MATULANE MAXAIR AUTOHALER MAXIPIME [INJ] MD TURBO MD-GASTROVIEW mebendazole meclizine hcl meclofenamate sodium medigesic medroxyprogesterone acetate mefloquine hcl MEGA C A PLUS [INJ] megaton megestrol acetate meloxicam melpaque hp melquin hp melquin-3 MENACTRA [INJ] MENEST MENOMUNE-A C Y W W DILUENT VL [INJ] MENOMUNE-A C Y W-135 [INJ] MENOPUR [INJ] meperidine hcl, w promethazine meperitab mephobarbital MEPHYTON meprobamate meprolone unipak MEPRON meprozine mercaptopurine MERIDIA * MERREM [INJ] MERUVAX II VACCINE W DILUENT [INJ] mesalamine MESNA [INJ] MESNEX MESTINON syrup, tab sa metadate er tab sa 20 mg METANX metaproterenol sulfate metformin hcl, er methadone, hcl, hydrochloride, intensol methadose methazolamide methenamine hippurate, mandelate METHERGINE methimazole METHITEST methocarbamol methotrexate methotrexate sodium [INJ] methyclothiazide methyldopa methyldopa hydrochlorothiazide methyldopate hcl [INJ] methylene blue [INJ] methylin tab 5 mg, 10 mg, 20 mg methylin er methylphenidate er, hcl methylprednisolone methylprednisolone acetate, sod succ [INJ] metipranolol metoclopramide metolazone metoprolol succinate, tartrate metoprolol-hydrochlorothiazide METROGEL * metronidazole metryl mexar mexiletine hcl mhp-a MIACALCIN inj mmiconazole 3 MICRO-K microgestin, fe MIDAZOLAM HCL inj 1 mg ml midazolam hcl inj 1 mg ml, 5 mg ml midazolam hcl syrup midodrine hcl migergot migquin MIGRANAL migratine migrin-a milrinone in 5% dextrose, lactate [INJ] minocycline hcl minoxidil mintex MINTEZOL mintuss dr, g, hc, hd, ms, nx MIRAPEX miraphen pse mirtazapine misoprostol mitomycin [INJ] mitoxantrone, hcl [INJ] MIXED VESPID VENOM PROTEIN, KIT [INJ] MOBAN mometasone furoate mononessa MONUROL morphine sulfate in dextrose [INJ] morphine sulfate, ir mst 600 multi vita-bets w fluoride MULTI-12 [INJ] multi-ret folic 500 multi-vit w fluoride & iron multifol MULTILYTE [INJ] MULTITRACE [INJ] MUMPSVAX VACCINE W DILUENT [INJ]! Will develop. People are more at risk of fungal infections if they have: recently taken a course of antibiotics an immune system weakened by cancer or HIV infection been taking oral steroids diabetes Moist skin encourages fungal infections. This means fungal infections are more likely when skin is not dried properly after sweating heavily or bathing, or when it is covered with a material that does not allow sweat to evaporate. Damage to the skin surface, such as a cut or graze, can also encourage fungi to grow. Fungal infections inside the body can cause more serious health problems than those on the skin. These infections only affect people whose immune systems are not working properly as a result of another illness or treatments for cancer. Animal fungi Humans are not usually affected by fungi that live on animals, although it is possible for some types to be caught from farmyard and domestic animals and parlodel. One is per day miconaz9le small percentage fluvoxamine learned. Of the treaty rules that were preventing members with insufficient or no manufacturing capacity in the pharmaceutical sector from making effective, public health focussed use of the flexibility said to be inherent in the compulsory licensing provisions of the trips agreement and periactin and miconazole, for example, miconazple ointment. For several months to identify any relapses. Only after an animal has had several negative cultures over several months can they be considered cured. Infected hairs that are shed and carried throughout the facility on fomites and air currents are the primary source for contagion. Clipping infected animals can dramatically reduce the number of infectious organisms on the hair coat. However, due to the risk of spreading active infection lesions ; , contaminating the facility and clippers, and zoonosis, the animal should be treated for at least 2 treatments before clipping. Clipping an infected animal can heavily contaminate the entire room. If clipping is required, the animals should be removed from the facility and clipped in a well ventilated area preferably outside away from all animals and human foot traffic. The clipped hair should be collected and disposed of immediately. Ideally, inexpensive clippers should be used and discarded after the animal has been clipped. It is almost impossible to effectively disinfect electric clippers that are contaminated with Microsporum canis. Continuing to use contaminated clippers is an efficient means to spread dermatophytosis. The authors do not clip infected animals unless they have long hair that is matted. Lime sulfur 4 oz gallon 25mg l ; applied every 3-7 days ; and 0.2% enilconazole applied twice each week ; are the only active ingredients that have repeatedly demonstrated high efficacy in clinical studies. 15-18 Enilconazole is only available in the United States as a poultry facility disinfectant and off label use is not permitted by the EPA. Lime sulfur is readily available and non-toxic. Due to its noxious odor, many operators refuse its use. Other active ingredients have demonstrated some benefit. Particularly noteworthy are the products that combine antifungal agents miconazole and chlorhexidine to produce a synergistic effect.19 These may help physically remove organisms and provide some antifungal activity. Systemic antifungals are highly efficacious and provide the best treatment modality. Many systemic antifungals are available which demonstrate good efficacy against M. canis Table 1 ; . 1-3, 20-27 Microsporum canis is particular difficult to treat with some strains demonstrating elevated MIC to the commonly used antifungal agents.28 New generation Imidazole antifungals demonstrate excellent activity and are the preferred treatment. Itraconazole and terbinafine are particularly effective and well tolerated even in cats. 20, 22-27 Both of these drugs have prolonged residual levels in the epidermis and hair and may help prevent the adherence of organisms to the skin.29, 30 This allows for flexible drug dosing pulse dosing ; while maintaining antifungal tissue levels. 22, 23 Unfortunately, as of this writing, itraconazole and terbinafine are relatively expensive treatments. Ketoconazole is widely available as a generic but is not well tolerated by cats. Lufenuron has received recent attention as a possible treatment for M. canis. 31, 32 In the original study, high doses demonstrated remarkable efficacy in both dogs and cats with dermatophytosis. 31 In more recent trials as well as anecdotal reports, lufenuron therapy has not provided sufficient antifungal activity to warrant its use as a sole therapeutic agent.33Lufenuron may provide some benefit but should be used as an adjunct to topical and systemic therapy. Microsporum canis vaccines have been repeatedly evaluated in the hope that the patient s immune system could be stimulated to prevent infection, speed resolution of an active infection, and prevent relapse. Unfortunately, vaccine trials have not been successful and currently there is no commercial vaccine available in the United States. 34-37 When to stop the treatments Every animal as well as the facility should be treated until several negative fungal cultures have been achieved. Repeated environmental cultures should be performed throughout the treatment period to monitor the disinfection process. It often requires 6 to 12 months to completely eradicate infectious organisms from a facility. Once treatments. Page 09 CAPSULE ENDOSCOPY AND NON-HAEMORRAGIC SMALL BOWEL DISEASES; PRELIMINARY RESULTS F BONFANTE, M TEBALDI, S PISTOSO AND W PIUBELLO Department of Internal Medicine and Endoscopic Unit, Hospital of Desenzano del Garda BS ; , Italy 10 EFFICIENCY OF ADDING 6 MERCAPTOPURINE 6 MP ; IN CORTICODEPENDENT ULCERATIVE COLITIS AND EFFICIENCY OF INFLIXIMAB INFL ; IN REFRACTORY ULCERATIVE COLITIS UC ; D OLTEANU, D LUPU, M ABBAS Internal Medicine I, University Hospital, Bucharest, Romania 11 SMAD3-KNOCKOUT MICE LACK INTERSTITIAL CELLS OF CAJAL IN THE COLONIC WALL G LATELLA1, A VETUSCHI2, R SFERRA2, A D'ANGELO1, V CATITTI1, G ZANNINELLI1, M CHIARAMONTE1, R CAPRILLI3 , E GAUDIO4 1 Cattedra di Gastroenterologia, Universit degli Studi di L'Aquila, Italy 2 Cattedra di Anatomia Umana, Universit degli Studi di L'Aquila, Italy 3 Cattedra di Gastroenterologia I, Universit degli Studi di Roma "La Sapienza", Italy 4 Cattedra di Anatomia Umana, Universit degli Studi di Roma "La Sapienza", Italy 12 COLONIC MUSCLE CELL DAMAGE INDUCED BY EXPOSURE OF HUMAN MUCOSA TO A PATHOGENIC LIPOPOLYSACCHARIDE IS MEDIATED BY OXIDATIVE STRESS AND BY PROSTAGLANDINS M GUARINO1, S CAROTTI1, C SEVERI2, G DI CUONZO3, I TATTOLI2, R ALLONI1, ALTOMARE1, M CICALA1 1 Dpt of Digestive Diseases of Campus Biomedico University 2 Dpt of Clinical Sciences, University La Sapienza 3 Dpt of Laboratory Medicine, Campus Biomedico University, Rome, Italy 13 PATIENTS WITH CLINICALLY DIFFERENT SYMPTOM-BASED DIAGNOSIS OF FUNCTIONAL BOWEL DISORDERS MAY HAVE IDENTICAL SPECIFIC AND NON SPECIFIC ILEO-COLO-RECTAL MICROSCOPIC ABNORMALITIES A MARCHEGGIANO1, A COVOTTA2, C IANNONI1, D BADIALI1, R CANTARINI1, M PAOLETTI2, N PALLOTTA1, E CORAZZIARI1 1 Dept Scienze Cliniche, University "La Sapienza", Rome, Italy 2 Department of Surgical Sciences, University "La Sapienza", Rome, Italy 14 RISK FACTORS OF IRRITABLE BOWEL SYNDROME IBS ; - LIKE SYMPTOMS IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE IBD ; C FIERBINTEANU-BRATICEVICI1, L TRIBUS1, P DRAGOMIR1, T BADESCU2, D ANDRONESCU1. 1 Medical Clinic II, Department of Gastroenterology, University Hospital, Bucharest 2 Medical Clinic, Department of Gastroenterology Bucharest, Romania 15 ULTRASOUND EVALUATION IN DIAGNOSIS AND FOLLOW-UP OF ACUTE COLONIC DIVERTICULITIS C FIERBINTEANU-BRATICEVICI, L NEGREANU, A BENGUS, R USVAT, D ANDRONESCU Medical ClinicII, Department of Gastroenterology, University Hospital, Bucharest, Romania and pioglitazone. Fig. 1. Inhibitory effects of HWY-289, miconazole, and CI-976 on C. albicans acyl-CoA: sterol acyltransferase in vivo. Reactions were started with 108 cells ml and pulse-radiolabeled with [3 H]oleate. Enzyme assays were performed with addition of different concentrations of HWY-289 s ; , miconazole d ; , and CI-976 ; in dimethyl sulfoxide, respectively. For more accurate determination of IC50 values, the concentrations of these compounds were serially twofold diluted from 1 to 32 lM. N.D, not determined.
|