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Multi-drug efflux systems. Microbiol. Rev. 60: 575-608. Paulsen, I. T., Cen, J., Nelson, K. E., and Saier, M. H., Jr. 2001. Comparative genomics of microbial drug efflux systems. J. Mol. Microbiol. Biotechnol. 3: 145-150. Paulsen, I. T., Park, J. H., Choi, P. S., and Saier, M. H. Jr. 1997. A family of Gram-negative bacterial outer membrane factors that function in export of proteins, carbohydrates, drugs and heavy metals from Gramnegative bacteria. FEMS Fed. Eur. Microbiol. Soc. ; Microbiol. Lett. 156: 1-8. Peng, W.-T., and Nester, E. W. 2001. Characterization of a putative RNDtype efflux system in Agrobacterium tumefaciens. Gene 270: 245-252. Poole, K. 2000. Efflux-mediated resistance to fluoroquinolones in gramnegative bacteria. Antimicrob. Agents Chemother. 44: 2233-2241. Poole, K., Krebes, K., McNally, C., and Neshat, S. 1993. Multiple antibiotic resistance in Pseudomonas aeruginosa: evidence for involvement of an efflux operon. J. Bacteriol. 175: 7363-7372. Pradel, E., and Pags, J.-M. 2002. The AcrAB-TolC efflux pump contributes to multidrug resistance in the nosocomial pathogen Enterobacter aerognes. Antimicrob. Agents Chemother. 46: 2640-2643. Psallidas, P. G., and Tsiantos, J. 2000. Chemical control of fire blight. Pages 199-234 in: Fire Blight: The Disease and Its Causative Agent, Erwinia amylovora. J. L. Vanneste, ed. CABI Publishing, Oxon, UK. Ramos, J. L., Duque, E., Godoy, P., and Segura, A. 1998. Efflux pumps involved in toluene tolerance in Pseudomonas putida DOT-T1E. J. Bacteriol. 80: 3323-3329. Saier, M. H., Jr., Beatty, J. T., Goffeau, A., Harley, K. T., Heijne, W. H., Huang, S. C., Jack, D. L., Jahn, P. S., Lew, K., Liu, J., Pao, S. S., Paulsen, I. T., Tseng, T. T., and Virk, P. S. 1999. The major facilitator superfamily. J. Mol. Microbiol. Biotechnol. 1: 257-279. Sambrook, J., and Russel, D. W. 2001. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. Schoonbeek, H., Del Sorbo, G., and De Waard, M. A. 2001. The ABC transporter BcatrB affects the sensitivity of Botrytis cinerea to the phytoalexin resveratrol and the fungicide fenpiclonil. Mol. Plant-Microbe Interact. 14: 562-571. Steinberger, E. M., and Beer, S. V. 1988. Creation and complementation of pathogenicity mutants of Erwinia amylovora. Mol. Plant-Microbe Interact. 1: 135-144. Sulavik, M. C., Houseweart, C., Cramer, C., Jiwani, N., Murgolo, N., Greene, J., DiDomenico, B., Shaw, K. J., Miller, G. H., Hare, R., and Shimer, G. 2001. Antibiotic susceptibility profiles of Escherichia coli strains lacking multi-drug efflux pump genes. Antimicrob. Agents Chemother. 45: 1126-1136. Treutter, D. 2001. Biosynthesis of phenolic compounds and its regulation in apple. Plant Grow. Regul. 34: 71-89. Tseng, T. T., Gratwick, K. S., Kollman, J., Park, D., Nies, D. H., Goffeau, A., and Saier, M. H., Jr. 1999. The RND permease superfamily: an ancient, ubiquitous and diverse family that includes human disease and development proteins. J. Mol. Microbiol. Biotechnol. 1: 107-125. Urban, M., Bhargava, T., and Hamer, J. E. 1999. An ATP-driven efflux pump is a novel pathogenicity factor in rice blast disease. EMBO J. 18: 512-521. van Bambeke, F., Balzi, E., and Tulkens, P. M. 2000. Antibiotic efflux pumps. Biochem. Pharmacol. 60: 457-470. VanEtten, H., Temporine, E., and Wasmann, C. 2001. Phytoalexin and Phytoanticipin ; tolerance as a virulence trait: why is it not required by all pathogens? Physiol. Mol. Plant Pathol. 59: 83-93. van Gijsegem, F. 1997. In planta regulation of phytopathogenic bacteria virulence genes: relevance of plant-derived signals. Eur. J. Plant Pathol. 103: 291-301. Vanneste, J. L. and Eden-Green, S. 2000. Migration of Erwinia amylovora in host plant tissue. Pages 9-36 in: Fire Blight: The Disease and Its Causative Agent, Erwinia amylovora. J. L. Vanneste, ed. CABI Publishing, Oxon, UK. Vanneste, J. L., Paulin, J.-P., and Expert, D. 1990. Bacteriophage Mu as a genetic tool to study Erwinia amylovora pathogenicity and hypersensitive reaction on tobacco. J. Bacteriol. 172: 932-941. Walsh, C. 2000. Molecular mechanisms that confer antibacterial drug resistance. Nature 406: 775-781. Wilson, K. 1994. Preparation of genomic DNA from bacteria. Pages 2.4.1.-2.4.5. in: Current Protocols in Molecular Biology. F. M. Ausubel, R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidmann, J. A. Smith, and K. Struhl, eds. John Wiley & Sons, NY. Wilson, K. J., Sessitsch, A., Corbo, J. C., Giller, K. E., Akkermans, A. D. L., and Jefferson, R. A. 1995. Glucuronidase GUS ; transposons for ecological and genetic studies of rhizobia and other Gram-negative bacteria. Microbiology 141: 1691-1705. Zgurskaya, H. I., and Nikaido, H. 2000. Multi-drug resistance mechanisms: drug efflux across two membranes. Mol. Microbiol. 37: 219-225. Brunet J, Eckert CG. 1998. Effects of floral morphology and display on outcrossing in blue columbine, Aquilegia caerulea Ranunculaceae ; . Functional Ecology 12: 596606. Carr DE, Fenster CB, Dudash MR. 1997. The relationship between mating-system characters and inbreeding depression in Mimulus guttatus. Evolution 51: 363372. Cesaro AC, Barrett SCH, Maurice S, Vaissiere BE, Thompson JD. 2004. An experimental evaluation of self-interference in Narcissus assoanus: functional and evolutionary implications. Journal of Evolutionary Biology 17: 13671376. Chang SM, Rausher MD. 1999. The role of inbreeding depression in maintaining the mixed mating system of the common morning glory, Ipomoea purpurea. Evolution 53: 13661376. Charlesworth D, Charlesworth B. 1987. Inbreeding depression and its evolutionary consequences. Annual Review of Ecology and Systematics 18: 237268. Cruzan MB. 1998. Genetic markers in plant evolutionary ecology. Ecology 79: 400412. Cruzan MB, Hamrick JL, Arnold ML, Bennett BD. 1994. Mating system variation in hybridizing irises: effects of phenology and floral densities on family outcrossing rates. Heredity 72: 95105. Darwin C. 1877. The different forms of flowers on plants of the same species. London: John Murray. Dorken ME, Friedman J, Barrett SCH. 2002. The evolution and maintenance of monoecy and dioecy in Sagittaria latifolia Alismataceae ; . Evolution 56: 3141. Eckert CG. 2000. Contributions of autogamy and geitonogamy to self-fertilization in a mass flowering, clonal plant. Ecology 81: 532542. Eckert CG, Barrett SCH. 1994. Inbreeding depression in partially selffertilizing Decodon verticillatus Lythraceae ; : population-genetic and experimental analyses. Evolution 48: 952964. Elle E, Hare JD. 2002. Environmentally induced variation in floral traits affects the mating system in Datura wrightii. Functional Ecology 16: 7988. Epperson BK, Clegg MT. 1987. First-pollination primacy and pollen selection in the morning glory, Ipomoea purpurea. Heredity 58: 514. Harder LD, Barrett SCH. 1995. Mating cost of large floral displays in hermaphrodite plants. Nature 373: 512515. Herlihy CR, Eckert CG. 2002. Genetic cost of reproductive assurance in a self-fertilizing plant. Nature 416: 320323. Herrera CM. 1995. Floral biology, microclimate, and pollination by ectothermic bees in an early-blooming herb. Ecology 76: 218228. Herrera CM, Hernandez-Bermejo E, Luque P, Benavente A. 1999. Narcissus longispathus Pugsley. In: Blanca G, Cabezudo B, Hernandez-Bermejo E, Herrera CM, Molero Mesa J, Mu~oz J, n Valdes B, eds. Libro rojo de la flora silvestre amenazada de Andalucia. I. Especies en peligro de extincion. Sevilla: Consejeria de Medio Ambiente, Junta de Andalucia, 191194. Holtsford TP, Ellstrand NC. 1992. Genetic and environmental variation in floral traits affecting outcrossing rate in Clarkia tembloriensis Onagraceae ; . Evolution 46: 216225. Ivey CT, Wyatt R. 1999. Family outcrossing rates and neighborhood floral density in natural populations of swamp milkweed Asclepias incarnata ; : potential statistical artifacts. Theoretical and Applied Genetics 98: 10631071. Karron JD, Jackson RT, Thumser NN, Schlicht SL. 1997. Outcrossing rates of individual Mimulus ringens genets are correlated with anther stigma separation. Heredity 79: 365370. Karron JD, Mitchell RJ, Holmquist KG, Bell JM, Funk B. 2004. The influence of floral display size on selfing rates in Mimulus ringens. Heredity 92: 242248. Leclerc-Potvin C, Ritland K. 1994. Modes of self-fertilization in Mimulus guttatus Scrophulariaceae ; --a field experiment. American Journal of Botany 81: 199205. Lee SL, Wickneswari R, Mahani MC, Zakri AH. 2000. Mating system parameters in a tropical tree species, Shorea leprosula Miq. Dipterocarpaceae ; , from Malaysian lowland dipterocarp forest. Biotropica 32: 693702. Lendvai G, Levin DA. 2003. Rapid response to artificial selection on flower size in Phlox. 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1% 11% DMHC2095 The preliminary trial results for the Canada-based Phase II trial see left trial in Figure Antiviral efficacy similar for all groups Datamonitor Published 04 2005 ; 23 ; summarized in Table 31 show that Page 151 monotherapy once every 14 days Albuferon This report is a licensed product and is not to be photocopied significant virological response in treatment-nave patients. This suggests leads to a Abbreviations: SC, subcutaneously. that the longer bioavailability of Albuferon correlates with significant drug efficacy. 8A1 APPORTIONMENT OF AMBIENT PRIMARY AND SECONDARY PM2.5 DURING A 2001 SUMMER STUDY IN THE NETL PITTSBURGH SITE USING PMF2 AND EPA UNMIX. Delbert J. Eatough, Brigham Young University Apportionment of primary and secondary pollutants during a July 2001 summer intensive study at the National Energy Technology Laboratory NETL ; , located about 18 kilometers southeast of downtown Pittsburgh based on collection of five samples per day will be described. PM2.5 was apportioned into primary and secondary contributions using the PMF2 multivariate receptor model and analysis software. The results were compared to previously reported apportionment for the same data set using the EPA UNMIX 2.3 program. The PMF2 analysis identified a total of eight primary plus secondary sources present for the PM2.5 collected at the NETL site. A combination of the PMF2 and UNMIX analyses allowed the identification of nine sources. The sources included primary crustal, and diesel and gasoline emissions which appeared to be of local origin, two small primary sources from the southeast and northwest which were consistent with emissions from coal-fired power plants and an industrial center, respectively, and a large transported source from the southwest Ohio River Valley ; which included both primary and secondary emissions. The latter source was the major source of both PM2.5 and of fine particulate sulfate. In addition, two local secondary sources and a secondary source from the northwest same location as the primary source from that direction ; were identified. The three major sources were, in order of decreasing significance, the transported source from the Ohio River Valley, one of the local secondary sources and the gasoline mobile source. These findings are consistent with the bulk of the secondary ammonium sulfate in the Pittsburgh area being the result of contributions from distant transport, and so decoupled from local activity involving organic pollutants in the metropolitan area. The major secondary sources were dominated by organic material and amphetamine.
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13.2.2.1.2 D ecision Point 8: Meta-Regression Model Robust? The purpose of Decision Point 8 is to evaluate the stability of any m od els d eveloped by m eta-regression analysis if perform ed ; . ECRI`s algorithm d ictates that the find ings of this evaluation categorize the evid ence base into one of tw o possible outcom es: original find ings stable, original find ings u nstable. For this system ic review , it w as ecid ed a priori that the stability of our m eta-regression analyses w ould be evaluated w ith a single analysis that consisted of repeating all m eta-regressions in an alternative m etric. If, follow ing this repeated analysis, the d ata w ere not best d escribed by the sam e m od el, our original find ings w ould be d eem ed unstable, for example, insomnia. Renal function is an important prognostic factor f r pa with acutely decompensated heart o t e failure ADHF ; . We investigated the renal eff c e ts nesiritide as treatment for A D H Randomized clinical trials comparing nesiritide with either placebo or active control for ADHF were identified by electronic and manual searches and thorough review of US Food and Drug Administration files available via the website. Worsening renal function was defined as an increase in serum creatinine 0.5 mg dL. Relative risk across all studies was determined by meta-analysis with Mantel-Haenszel fixede e ts models RRM H ; . Risk of dialysis and ff c medical intervention for worsening renal function were compared between therapies. Frequency of worsening renal function was determined from 5 randomized studies that included 1269 pa i n ts. Use of Food and Drug Administrationapproved doses of nesiritide 0.03 g kg-1 m n-1 ; i significantly increased the risk of worsening renal function compared with non-inotropebased control RRM H, 1.52; 95% CI, 1.16 to 2.00 and atrovent.

1. Ground testing must be completed prior operational use of dextro-amphetamine Dexedrine ; , Amb9en or Temazepam Restoril ; . No flying will be done the day of the pretest. Both the SF-600 overlay and the Informed Consent form will be completed, signed by the member and placed in the medical record. 2. Fully brief all aviators and supervisory personnel on the proper use of medications and possible side-effects. 3. Ensure the Commanding Officer has properly authorized use of the medication. Consult with your own supervising medical officer. 4. Issue the stimulant in amounts required for one or two flights and document with an SF-600 entry. Sedatives will not be carried in the airplane to preclude inadvertent use. 5. Closely monitor medication use and aviator fatigue by being present as much as possible in the ready room. Pay particular attention to possible interactions with over-the-counter medications. 6. Collect unused medication at the end of continuous operations. 7. Submit a report to the Chairman of the Aeromedical Advisory Council, Naval Operational Medicine Institute, describing both the operational tasking and use of anti-fatigue medications. Commanding Officer. ACEIs work by blocking an enzyme that leads to the release of a substance called angiotensin, which causes blood vessels to constrict. Thus, ACEIs relax blood vessels throughout the body, lowering blood pressure and reducing the workload on the heart. ACEIs are not the best initial choice for many people with high blood pressure. Recent studies indicate that inexpensive generic diuretics often called water pills ; are a better first choice, especially for people who have high blood pressure but no other heart problems or diabetes. Those studies show that diuretics can prevent heart attacks, heart failure, strokes, and deaths as effectively as ACEIs or other classes of high blood pressure drugs. Some people who are already taking a diuretic, however, and need a second drug to lower their blood pressure can benefit from taking an ACEI. If you fall in this category -- needing a second blood pressurelowering drug -- your doctor will be weighing the relative merits of giving you an ACEI, a beta-blocker or another type of drug, based on your individual medical circumstances. ACEIs are usually or often a first choice, however, if you have one or more of the following conditions, with or without high blood pressure: Heart failure Heart attack myocardial infarction ; or stroke in the past Diabetes Diabetic kidney disease In particular, ACEIs have become a cornerstone of treatment for heart failure. They effectively -- some and augmentin.

Although treatment of LTBI will be essential to ultimately eliminating TB, little effort is being focused on improving preventive therapy for drug-susceptible TB. Furthermore, there are no efforts at all to use novel agents as preventive therapy to avoid active disease in persons exposed to infectious cases of multi- and or extensively drug resistant TB M XDR-TB.

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These items may be used, while pending, results, to offset medical allowance list requirements. h. The pharmacy shall maintain, in the pertinent clinic areas, an adequate supply of emergency medications or kits ; , poison antidotes, and the National Poison Control Center telephone number 1-800-222-1222 ; . Containers for these items shall be closed with break-away seals to prevent the unreported removal of items. The outside of the container shall post an inventory list with the expiration dates of dated items. i. Where feasible, pharmacies shall establish borrowing policies with local Government or civilian pharmacies to cover temporary supply shortfalls. The person responsible for the pharmacy shall maintain a log of items loaned or borrowed, and review and initial the log weekly to ensure prompt replacement of all items. 9. Pharmacy and Therapeutics Committee. a. This is a mandatory advisory committee in all Coast Guard health service treatment facilities having assigned medical officers and shall meet quarterly at least four times a year ; . The committee is composed of, but not limited to the following: at least one physician, one dental officer, a pharmacy officer when available ; , and a representative from medical administration. The chairman shall be a physician member. When a pharmacist is assigned, he or she is the secretary of this committee. b. The committee is an advisory group on all matters relating to the acquisition and use of medications. Its recommendations are subject to the approval of the Chief, Health Services Division. The basic responsibilities of this committee are to: 1 ; Use the Department of Defense Basic Core Formulary DoD BCF ; as guidance to develop and maintain a clinic drug formulary as specified in 10-A-2.c.; the group reviews newly requested items and deletes unnecessary items. Maintain a unit formulary ensuring items authorized for health service technicians based on the authorized Coast Guard Standardized Health Services Technician Formulary ; is properly notated; Ensure the unit formulary does not include items based primarily on civilian prescriber demand; Prevent unnecessary therapeutic duplications of formulary products; Conduct an ongoing review of all non-formulary items the pharmacy procures and dispenses. To accomplish this, the clinic and or P&T committee lists: a ; b ; 6 ; list of all clinic formulary items not currently in the DoD BCF; A list of all special order items and the patients for whom procured.
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If you are not sure what category to look under, you should look for your drug in the Table of Contents that begins on page 49. The Table of Contents provides an alphabetical list of all of the drugs included in this document. Both brand-name drugs and generic drugs are listed in the Table of Contents. Look in the Table of Contents and find your drug. Next to your drug, you will see the page number where you can find coverage information. Turn to the page listed in the Table of Contents and find the name of your drug in the first column of the list.

Sleep-Driving A couple of weeks ago the popular press was full of reports on so-called Amgien zombies; apparently a very few users of the sleep aid experienced such deleterious side-effects as sleep-walking, sleep-eating, and sleep-driving. The problem first cropped up in traffic court dockets. To the many of us who drive to work each day, the stories on talk radio seemed to explain some of the more bizarre behavior we witness on highways. But to wizened old investors like myself, I found the glaring headlines a bit suspect. I, for one, do not think that our interstates were being threatened by drug-addled zombies nor. Ture. This would make it possible to locate telemetry patients immediately in the event of an alarm. Using such or similar technology would also allow developing smarter, ambient aware user interfaces and functions. In detox, they give you ambien for sleep, but i'm thinking since you're already taking it, it probably does little more than take the edge off your withdrawal and amitriptyline. Buy ambien snorting ambien is ambien use buy ambien ambien on line related to site ambien and ambien drug test resources.

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World at large. I would like to take this opportunity to thank all the student officers, from your presidents down, that work tirelessly in a very stressful and often thankless job on behalf of all London medics. The coming months will see the first cohort of doctors entering F1. The London officers have worked extremely hard in pushing students views to ensure that any problems are minimised. London has been in the forefront of this work nationally, making sure students are accurately represented. I wish the new doctors the best of luck with the foundation programmes and hope that the work we have done pays off. We will see preparations being made for freshers next year, as well as the new finalists preparing for their job applications and all that follows medical school. ULU will of course continue to support the five schools strongly, with a new ULU MSO - Simon Lammy, from RUMS, to lead medical students in London for the next year. He promises to be an excellent face of London medics and I encourage anyone with any questions or problems to get in touch with him. Have a great summer and good luck to everyone with their exams.
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